Scholarlink

Objectives <p>To use finite element (FE) modeling and in vivo optical coherence tomography (OCT) imaging to explore the effect of ciliary muscle traction on optic nerve head (ONH) deformation during accommodation.</p> Methods <p>We developed a FE model to mimic the ciliary muscle traction during accommodation, and varied the stiffness of the sclera, choroid, Bruch’s membrane (BM), prelaminar neural tissue and lamina cribrosa (LC) to assess their effects on accommodation-induced ONH strains. To validate the FE model, OCT images of the right eyes’ ONHs from 20 subjects (25 ± 1.5 years, range: 24–28 years) were taken for an accommodative stimulus of 6-diopters (6D) and a relaxed state of 0D. Based on OCT images, the accommodation-induced ONH effective strains, choroidal thickness and BM opening (BMO) changes were measured.</p> Results <p>Our FE model predicted that the ciliary muscle pulling force could be transmitted to the ONH through the choroid and BM. The LC strain caused by the ciliary muscle pulling (0.0177) is comparable to that induced by an IOP elevation of 45 mmHg (0.0173). The accommodation-induced LC strain increased with stiffer choroid and BM. Three-dimensional strain tracking showed that the LC strains under 6D and 0D accommodation were 0.057 ± 0.033 and 0.023 ± 0.014 (<i>p</i> &lt; 0.05). The reduction in choroidal thickness and the enlargement in BMO were observed during accommodation.</p> Conclusions <p>Our study showed that during accommodation, ciliary muscle traction could induce large ONH deformations and that stiffer choroid and BM increased the pulling force transmitted to the ONH, thereby leading to higher LC strains.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ciliary muscle traction during accommodation is able to induce optic nerve head deformation

  • 期刊论文

  • 发表日期：

    2025年1月4日

查看全文
  • Tingting Liu,
  • Kehao Wang,
  • Ya Xing Wang,
  • Xiaoyu Liu,
  • Jingyun Han,
  • Michael J. A. Girard,
  • Barbara K. Pierscionek,
  • Xiaofei Wang,
  • Yubo Fan

摘要

Objectives

To use finite element (FE) modeling and in vivo optical coherence tomography (OCT) imaging to explore the effect of ciliary muscle traction on optic nerve head (ONH) deformation during accommodation.

Methods

We developed a FE model to mimic the ciliary muscle traction during accommodation, and varied the stiffness of the sclera, choroid, Bruch’s membrane (BM), prelaminar neural tissue and lamina cribrosa (LC) to assess their effects on accommodation-induced ONH strains. To validate the FE model, OCT images of the right eyes’ ONHs from 20 subjects (25 ± 1.5 years, range: 24–28 years) were taken for an accommodative stimulus of 6-diopters (6D) and a relaxed state of 0D. Based on OCT images, the accommodation-induced ONH effective strains, choroidal thickness and BM opening (BMO) changes were measured.

Results

Our FE model predicted that the ciliary muscle pulling force could be transmitted to the ONH through the choroid and BM. The LC strain caused by the ciliary muscle pulling (0.0177) is comparable to that induced by an IOP elevation of 45 mmHg (0.0173). The accommodation-induced LC strain increased with stiffer choroid and BM. Three-dimensional strain tracking showed that the LC strains under 6D and 0D accommodation were 0.057 ± 0.033 and 0.023 ± 0.014 (p < 0.05). The reduction in choroidal thickness and the enlargement in BMO were observed during accommodation.

Conclusions

Our study showed that during accommodation, ciliary muscle traction could induce large ONH deformations and that stiffer choroid and BM increased the pulling force transmitted to the ONH, thereby leading to higher LC strains.