Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

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2024年7月4日

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João M. Furtado,
Jost B. Jonas,
Ian Tapply,
Arthur G. Fernandes,
Maria Vittoria Cicinelli,
Alessandro Arrigo,
Nicolas Leveziel,
Serge Resnikoff,
Hugh R. Taylor,
Tabassom Sedighi,
Seth Flaxman,
Maurizio Battaglia Parodi,
Mukkharram M. Bikbov,
Tasanee Braithwaite,
Alain Bron,
Ching-Yu Cheng,
Nathan Congdon,
Monte A. Del Monte,
Joshua R. Ehrlich,
Tim Fricke,
David Friedman,
Gus Gazzard,
M. Elizabeth Hartnett,
Rim Kahloun,
John H. Kempen,
Moncef Khairallah,
Rohit C. Khanna,
Judy E. Kim,
Van Charles Lansingh,
Janet Leasher,
Kovin S. Naidoo,
Vinay Nangia,
Michal Nowak,
Konrad Pesudovs,
Tunde Peto,
Pradeep Ramulu,
Fotis Topouzis,
Mitiadis Tsilimbaris,
Ya Xing Wang,
Ningli Wang,
Rupert R. A. Bourne,
João M. Furtado,
Jost B. Jonas,
Arthur G. Fernandes,
Maria Vittoria Cicinelli,
Nicolas Leveziel,
Paul Svitil Briant,
Theo Vos,
Serge Resnikoff,
Florian Fischer,
Yohannes Habtegiorgis Abate,
Mohammad Abdollahi,
Tadele Girum Girum Adal,
Isaac Yeboah Addo,
Kishor Adhikari,
Prerna Agarwal,
Antonella Agodi,
Williams Agyemang-Duah,
Aqeel Ahmad,
Hamid Ahmadieh,
Hooman Ahmadzadeh,
Fares Alahdab,
Ahmad Samir Alfaar,
Robert Kaba Alhassan,
Syed Shujait Shujait Ali,
Louay Almidani,
Sofia Androudi,
Abhishek Anil,
Anayochukwu Edward Anyasodor,
Jalal Arabloo,
Mubarek Yesse Ashemo,
Seyyed Shamsadin Athari,
Desta Debalkie Atnafu,
Alok Atreya,
Melese Kitu Ayalew,
Yared Asmare Aynalem,
Zewdu Bishaw Aynalem,
Ahmed Y. Azzam,
Sara Bagherieh,
Ruhai Bai,
Martina Barchitta,
Mainak Bardhan,
Till Winfried Bärnighausen,
Nebiyou Simegnew Bayileyegn,
Fatemeh Bazvand,
Ahmet Begde,
Babak Behnam,
Akshaya Srikanth Bhagavathula,
Sonu Bhaskar,
Gurjit Kaur Bhatti,
Jasvinder Singh Bhatti,
Bagas Suryo Bintoro,
Marina G. Birck,
Tasanee Braithwaite,
Katrin Burkart,
Yasser Bustanji,
Florentino L. Caetano dos Santos,
Vera L. A. Carneiro,
Muthia Cenderadewi,
Vijay Kumar Chattu,
Dinh-Toi Chu,
Kaleb Coberly,
Natália Cruz-Martins,
Omid Dadras,
Xiaochen Dai,
Ana Maria Dascalu,
Mohsen Dashti,
Anna Dastiridou,
Maedeh Dastmardi,
Xinlei Deng,
Nikolaos Dervenis,
Vinoth Gnana Chellaiyan Devanbu,
Mengistie Diress,
Shirin Djalalinia,
Joshua R. Ehrlich,
Michael Ekholuenetale,
Temitope Cyrus Ekundayo,
Iman El Sayed,
Muhammed Elhadi,
Mehdi Emamverdi,
Ambaw Abebaw Emrie,
Adeniyi Francis Fagbamigbe,
Ayesha Fahim,
Umar Farooq,
Hossein Farrokhpour,
Ali Fatehizadeh,
Alireza Feizkhah,
Lorenzo Ferro Desideri,
Getahun Fetensa,
Bikila Regassa Feyisa,
Seth Flaxman,
Ali Forouhari,
Matteo Foschi,
Kayode Raphael Fowobaje,
Aravind P. Gandhi,
Tilaye Gebru Gebi,
Miglas W. Gebregergis,
Mesfin Gebrehiwot,
Brhane Gebremariam,
Gebreamlak Gebremedhn Gebremeskel,
Yibeltal Yismaw Gela,
Molalegn Mesele Gesese,
Khalil Ghasemi Falavarjani,
Fariba Ghassemi,
Sherief Ghozy,
Mahaveer Golechha,
Pouya Goleij,
Sapna Gupta,
Veer Bala Gupta,
Vivek Kumar Gupta,
Teklehaimanot Gereziher Haile,
Semira Goitom Hailu,
Arvin Haj-Mirzaian,
Aram Halimi,
Shahin Hallaj,
Billy Randall Hammond,
Ikramul Hasan,
Hamidreza Hasani,
Hossein Hassanian-Moghaddam,
Mahsa Heidari-Foroozan,
Sung Hwi Hong,
Praveen Hoogar,
Mehdi Hosseinzadeh,
Chengxi Hu,
Hong-Han Huynh,
Mustapha Immurana,
Chidozie C. D. Iwu,
Louis Jacob,
Abdollah Jafarzadeh,
Mihajlo Jakovljevic,
Shubha Jayaram,
Mohammad Jokar,
Nitin Joseph,
Charity Ehimwenma Joshua,
Gebisa Guyasa Kabito,
Laleh R. Kalankesh,
Sagarika Kamath,
Himal Kandel,
Ibraheem M. Karaye,
Hengameh Kasraei,
Gbenga A. Kayode,
Shemsu Kedir,
Yousef Saleh Khader,
Himanshu Khajuria,
Moawiah Mohammad Khatatbeh,
Mahalaqua Nazli Khatib,
Zahra Khorrami,
Yun Jin Kim,
Adnan Kisa,
Sezer Kisa,
Soewarta Kosen,
Ai Koyanagi,
Kewal Krishan,
Chandrakant Lahariya,
Tri Laksono,
Dharmesh Kumar Lal,
Van Charles Lansingh,
Trang D. T. Le,
Janet L. Leasher,
Munjae Lee,
Seung Won Lee,
Wei-Chen Lee,
Stephen S. Lim,
Xuefeng Liu,
Alireza Mahmoudi,
Razzagh Mahmoudi,
Kashish Malhotra,
Vahid Mansouri,
Roy Rillera Marzo,
Andrea Maugeri,
Colm McAlinden,
Tesfahun Mekene Meto,
Abera M. Mersha,
Tomislav Mestrovic,
Ephrem Tesfaye Mihretie,
Mehdi Mirzaei,
Prasanna Mithra,
Nouh Saad Mohamed,
Soheil Mohammadi,
Abdulwase Mohammed,
Ali H. Mokdad,
Hossein Molavi Vardanjani,
Mohammad Ali Moni,
Fateme Montazeri,
Maryam Moradi,
Parsa Mousavi,
Ahmed Nuru Muhamed,
Admir Mulita,
Kovin S. Naidoo,
Ganesh R. Naik,
Shumaila Nargus,
Zuhair S. Natto,
Biswa Prakash Nayak,
Mohammad Negaresh,
Hadush Negash,
Seyed Aria Nejadghaderi,
Dang H. Nguyen,
Hien Quang Nguyen,
Phat Tuan Nguyen,
Van Thanh Nguyen,
Robina Khan Niazi,
Mamoona Noreen,
Ogochukwu Janet Nzoputam,
Ismail A. Odetokun,
Andrew T. Olagunju,
Matthew Idowu Olatubi,
Obinna E. Onwujekwe,
Michal Ordak,
Uchechukwu Levi Osuagwu,
Nikita Otstavnov,
Mayowa O. Owolabi,
Jagadish Rao Padubidri,
Parsa Panahi,
Ashok Pandey,
Shahina Pardhan,
Jay Patel,
Venkata Suresh Patthipati,
Shrikant Pawar,
Arokiasamy Perianayagam,
Ionela-Roxana Petcu,
Hoang Tran Pham,
Ibrahim Qattea,
Pankaja Raghav Raghav,
Fakher Rahim,
Vafa Rahimi-Movaghar,
Mohammad Hifz Ur Rahman,
Mosiur Rahman,
Premkumar Ramasubramani,
Ahmed Mustafa Rashid,
Annisa Utami Rauf,
Elrashdy Moustafa Mohamed Redwan,
Nazila Rezaei,
Priyanka Roy,
Zahra Saadatian,
Siamak Sabour,
Basema Saddik,
Umar Saeed,
Sare Safi,
Sher Zaman Safi,
Amene Saghazadeh,
Fatemeh Saheb Sharif-Askari,
Narjes Saheb Sharif-Askari,
Amirhossein Sahebkar,
Joseph W. Sakshaug,
Saina Salahi,
Sarvenaz Salahi,
Mohamed A. Saleh,
Yoseph Leonardo Samodra,
Vijaya Paul Samuel,
Abdallah M. Samy,
Aswini Saravanan,
Monika Sawhney,
Mete Saylan,
Sayed Mansoor Sediqi,
Siddharthan Selvaraj,
Yashendra Sethi,
Allen Seylani,
Jaffer Shah,
Samiah Shahid,
Moyad Jamal Shahwan,
Masood Ali Shaikh,
Muhammad Aaqib Shamim,
Maryam Shayan,
Mika Shigematsu,
Aminu Shittu,
Seyed Afshin Shorofi,
Emmanuel Edwar Siddig,
Juan Carlos Silva,
Jasvinder A. Singh,
Paramdeep Singh,
Eirini Skiadaresi,
Raúl A. R. C. Sousa,
Chandrashekhar T. Sreeramareddy,
Vladimir I. Starodubov,
Birhan Tsegaw Taye,
Jansje Henny Vera Ticoalu,
Guesh Mebrahtom Tsegay,
Miltiadis K. Tsilimbaris,
Saif Ullah,
Muhammad Umair,
Sahel Valadan Tahbaz,
Nuwan Darshana Wickramasinghe,
Guadie Sharew Wondimagegn,
Lin Yang,
Arzu Yiğit,
Dong Keon Yon,
Naohiro Yonemoto,
Yuyi You,
Mikhail Sergeevich Zastrozhin,
Hanqing Zhao,
Peng Zheng,
Makan Ziafati,
Magdalena Zielińska,
Jaimie D. Steinmetz,
Rupert R. A. Bourne

摘要

Background

We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD).

Methods

We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness ( < 3/60) caused by AMD, stratified by age, region, and year.

Results

In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%.

Conclusions

The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.