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Aqueous humour interleukin-6 and vision outcomes with anti-vascular endothelial growth factor therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年4月15日

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  • Yasir Jamal Sepah,
  • Diana V. Do,
  • Marina Mesquida,
  • Bann-Mo Day,
  • Steven Blotner,
  • Rubbia Afridi,
  • Muhammad Sohail Halim,
  • Kyu Hong,
  • Eric Wakshull,
  • Sascha Fauser,
  • Ivaylo Stoilov,
  • Quan Dong Nguyen,
  • P. Abraham,
  • D. V. Alfaro III,
  • A. Antoszyk,
  • M. Antworth,
  • B. Baker,
  • C. Baker,
  • M. Balles,
  • D. Boyer,
  • W. Bridges Jr,
  • D. M. Brown,
  • B. Busbee,
  • M. Busquets,
  • C. Chan,
  • N. Chaudhry,
  • S. Chen,
  • J. Christoforidis,
  • T. Ciulla,
  • W. L. Clark,
  • T. Cleland,
  • T. Connor,
  • A. Daccache,
  • A. Dessouki,
  • K. Diddie,
  • B. Doft,
  • R. Dreyer,
  • D. W. Faber,
  • L. Feiner,
  • R. Feldman,
  • P. Ferrone,
  • G. Fox,
  • S. Foxman,
  • R. Frenkel,
  • A. Fung,
  • R. Gallemore,
  • T. Ghuman,
  • V. Gonzalez,
  • A. Gordon,
  • C. Gordon,
  • S. Gupta,
  • S. Hariprasad,
  • J. Heier,
  • A. Ho,
  • D. Holmes,
  • J. Huang,
  • J. P. Hubschman,
  • H. Hudson,
  • D. Ie,
  • R. Johnson,
  • R. Katz,
  • S. Kiss,
  • J. Kitchens,
  • G. Kokame,
  • E. Lit,
  • M. Liu,
  • J. K. Luu,
  • M. MacCumber,
  • S. Madreperla,
  • D. Marcus,
  • A. Martidis,
  • J. Martinez,
  • M. Michels,
  • D. Miller,
  • L. Morse,
  • M. Nasir,
  • Q. Nguyen,
  • S. Oliver,
  • K. Olsen,
  • S. Patel,
  • P. Pavan,
  • J. Pearlman,
  • J. Prenner,
  • C. Regillo,
  • E. Reichel,
  • R. Rosa,
  • S. Rose,
  • S. Sadda,
  • M. Samuel,
  • L. Singerman,
  • M. Singer,
  • R. Singh,
  • G. Stoller,
  • I. Suner,
  • A. Tabassian,
  • B. Taney,
  • A. Thach,
  • M. Thomas,
  • M. Tolentino,
  • D. Tom,
  • P. Tornambe,
  • R. Torti,
  • S. Truong,
  • T. Verstraeten,
  • A. Wagner,
  • K. Wald,
  • P. Weber,
  • P. Weishaar,
  • M. Wieland,
  • D. Williams,
  • T. Wong,
  • M. Wood,
  • J. Wroblewski,
  • K. Zhang,
  • D. V. Do,
  • E. Lit,
  • E. Kruger,
  • J. Pollack,
  • L. Halperin,
  • M. Bennett,
  • D. Boyer,
  • D. Callanan,
  • K. Zhang,
  • A. Symons,
  • P. Abraham

摘要

Background

This analysis evaluated aqueous humour (AH) interleukin (IL)-6 concentrations and the association between AH IL-6 and visual outcomes in patients with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DMO) receiving anti–vascular endothelial growth factor (VEGF) monotherapy.

Methods

Post hoc analysis of the multicentre, double-masked, randomised HARBOR (NCT00891735) and READ-3 (NCT01077401) trials. HARBOR enrolled treatment-naïve nAMD patients. READ-3 enrolled treatment-naïve/previously treated DMO patients. HARBOR patients received ranibizumab 0.5 or 2.0 mg monthly or as needed; AH samples were collected at month 2, after two previous intravitreal injections. READ-3 patients received ranibizumab 0.5 or 2.0 mg as needed; AH samples were collected at baseline and months 3, 6, 9, and 12. Main outcome measure: association between AH IL-6 concentrations and month 24 best-corrected visual acuity (BCVA).

Results

In both trials (HARBOR, N = 36; READ-3, N = 137), patients with higher AH IL-6 concentrations had worse visual outcomes. HARBOR patients with low AH IL-6 concentrations at month 2 had a mean (95% CI) BCVA change at month 24 of +2.9 (−2.6, 8.3) letters, whereas patients with high AH concentrations had a mean (95% CI) BCVA change of −9.0 (−22.7, 4.7) letters. READ-3 patients with low AH concentrations at baseline had a mean (95% CI) BCVA change at month 12 of +9.3 (7.4, 11.3) letters, whereas patients with high AH concentrations had a mean (95% CI) BCVA change of +5.6 (2.2, 9.1) letters.

Conclusions

Higher IL-6 AH concentrations may predict suboptimal visual responses to anti–VEGF monotherapy in patients with nAMD/DMO.