Scholarlink

<p>With increasing availability of genetic tests, it is important to consider differences in testing patterns between population subgroups. We examined self-reported genetic testing among 45,061 participants of the Australian population-based 45 and Up Study, testing for associations with sociodemographic and health characteristics (multivariable logistic regression). 9.2% of participants reported ever having genetic testing; 3.9% reported disease-related testing, 5.2% non-disease-related testing, 0.7% both disease-related and non-disease-related testing. Disease-related genetic testing was strongly associated with younger age, female sex, history of cancers and cardiovascular disease, and cancer family history. Disease-related testing was also strongly associated with higher education (university <i>versus</i> school certificate: adjusted OR [aOR] = 1.50 [95%CI:1.29–1.75]; certificate/diploma <i>versus</i> school certificate: aOR = 1.40 [95%CI:1.20–1.63]); there was suggestive evidence for association with higher household income ($AUD90,000+ <i>versus</i> &lt;$AUD30,000: aOR = 1.22 [95%CI:1.02–1.46]), which strengthened when not adjusting for education (aOR = 1.34 [95%CI:1.13–1.60]). These results suggest further work on ensuring equitable access is needed to prevent potential health inequities.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sociodemographic and health factors associated with genetic testing in Australia: insights from a cohort-based study of 45,061 participants

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月27日

查看全文
  • David E. Goldsbury,
  • Yoon-Jung Kang,
  • Catherine Tang,
  • Hamzeh M. Tanha,
  • Amelia K. Smit,
  • Kate L. A. Dunlop,
  • Lara Petelin,
  • Preston Ngo,
  • Harriet Hui,
  • Nicola S. Meagher,
  • Melissa A. Merritt,
  • Marianne Weber,
  • Anna DeFazio,
  • Anne E. Cust,
  • Karen Canfell,
  • Julia Steinberg

摘要

With increasing availability of genetic tests, it is important to consider differences in testing patterns between population subgroups. We examined self-reported genetic testing among 45,061 participants of the Australian population-based 45 and Up Study, testing for associations with sociodemographic and health characteristics (multivariable logistic regression). 9.2% of participants reported ever having genetic testing; 3.9% reported disease-related testing, 5.2% non-disease-related testing, 0.7% both disease-related and non-disease-related testing. Disease-related genetic testing was strongly associated with younger age, female sex, history of cancers and cardiovascular disease, and cancer family history. Disease-related testing was also strongly associated with higher education (university versus school certificate: adjusted OR [aOR] = 1.50 [95%CI:1.29–1.75]; certificate/diploma versus school certificate: aOR = 1.40 [95%CI:1.20–1.63]); there was suggestive evidence for association with higher household income ($AUD90,000+ versus <$AUD30,000: aOR = 1.22 [95%CI:1.02–1.46]), which strengthened when not adjusting for education (aOR = 1.34 [95%CI:1.13–1.60]). These results suggest further work on ensuring equitable access is needed to prevent potential health inequities.