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<p>The prognostic value of body composition phenotypes in coronary artery disease (CAD) remains underexplored. We retrospectively analyzed 178 CAD inpatients who underwent bioelectrical impedance analysis (InBody 770). K-means clustering using skeletal muscle index (SMI) and body fat percentage (PBF) as primary discriminators identified three phenotypes: Sarcopenic (lowest SMI, ~5.3 kg/m²), Robust (highest SMI, ~7.6 kg/m²), and Sarcopenic-Obesity (low SMI ~ 5.8 kg/m² and high PBF ~ 36.9%). Multivariate logistic regression assessed their associations with cardiovascular outcomes. The Sarcopenic-Obesity phenotype showed the highest prevalence of arrhythmias (39.6%) and heart failure (62.5%) and was independently associated with arrhythmias (OR 2.58, 95% CI 1.17–5.87) and heart failure (OR 2.42, 95% CI 1.18–5.21). Phase angle inversely correlated with ECW/TBW (r = –0.83, <i>p</i> &lt; 0.001) and discriminated heart failure (AUC = 0.72). Body composition phenotyping, especially sarcopenic obesity, identifies high-risk CAD inpatients beyond traditional factors.</p>

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Association between body composition phenotypes and cardiovascular outcomes in patients with coronary artery disease: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2026年7月25日

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  • Tingting Wu,
  • Hongying Li,
  • Liao He,
  • Xiaoli Yang,
  • Junyi Yu,
  • Chunmei Xu,
  • Qian He

摘要

The prognostic value of body composition phenotypes in coronary artery disease (CAD) remains underexplored. We retrospectively analyzed 178 CAD inpatients who underwent bioelectrical impedance analysis (InBody 770). K-means clustering using skeletal muscle index (SMI) and body fat percentage (PBF) as primary discriminators identified three phenotypes: Sarcopenic (lowest SMI, ~5.3 kg/m²), Robust (highest SMI, ~7.6 kg/m²), and Sarcopenic-Obesity (low SMI ~ 5.8 kg/m² and high PBF ~ 36.9%). Multivariate logistic regression assessed their associations with cardiovascular outcomes. The Sarcopenic-Obesity phenotype showed the highest prevalence of arrhythmias (39.6%) and heart failure (62.5%) and was independently associated with arrhythmias (OR 2.58, 95% CI 1.17–5.87) and heart failure (OR 2.42, 95% CI 1.18–5.21). Phase angle inversely correlated with ECW/TBW (r = –0.83, p < 0.001) and discriminated heart failure (AUC = 0.72). Body composition phenotyping, especially sarcopenic obesity, identifies high-risk CAD inpatients beyond traditional factors.