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<p>A recent animal study suggested that olive oil or other oleic acid-enriched food sources promote adiposity. In contrast, human evidence indicates neutral or protective effects on weight gain. Reconciling these divergent findings is crucial for understanding the role of olive oil, specifically oleic acid, in metabolism. In this Perspective, we contrast the animal study with evidence in humans, emphasizing the context in which each body of research was generated. We also highlight key limitations for translating results from controlled animal experiments to humans. Olive oil, beyond being a traditional culinary fat, serves as a major dietary source of monounsaturated fatty acids in Mediterranean-style diets, where its consumption has been consistently linked to favorable metabolic profiles. Our Perspective emphasizes the need for comprehensive metabolic phenotyping in mice, which can facilitate translation to humans.</p>

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Role of olive oil in weight gain: contrasting the animal and human findings

  • 期刊论文

  • 发表日期：

    2026年3月17日

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  • Jose E. Galgani,
  • Rodrigo Fernández-Verdejo,
  • Miguel A. Martínez-González

摘要

A recent animal study suggested that olive oil or other oleic acid-enriched food sources promote adiposity. In contrast, human evidence indicates neutral or protective effects on weight gain. Reconciling these divergent findings is crucial for understanding the role of olive oil, specifically oleic acid, in metabolism. In this Perspective, we contrast the animal study with evidence in humans, emphasizing the context in which each body of research was generated. We also highlight key limitations for translating results from controlled animal experiments to humans. Olive oil, beyond being a traditional culinary fat, serves as a major dietary source of monounsaturated fatty acids in Mediterranean-style diets, where its consumption has been consistently linked to favorable metabolic profiles. Our Perspective emphasizes the need for comprehensive metabolic phenotyping in mice, which can facilitate translation to humans.