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Background/objectives <p>Serum total antioxidant capacity (sTAC) and uric acid (SUA) levels have been related to oxidative stress in metabolic diseases. Nevertheless, the evidence in epidemiological studies is still scarce and inconsistent. We aimed to evaluate the association between sTAC, SUA, obesity, and cardiometabolic traits in Mexican children.</p> Subjects/methods <p>This cross-sectional study analyzed anthropometric data, blood pressure, cardiometabolic traits, and SUA levels of 248 children with normal weight (NW) and 255 with obesity (OB). sTAC was measured with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method.</p> Results <p>sTAC was directly related to SUA (β = 0.905 ± 0.358, <i>p</i> = 0.012). Obesity was positively associated with sTAC (β = 0.075 ± 0.020, <i>p</i> &lt; 0.001) and SUA (β = 0.706 ± 0.129, <i>p</i> &lt; 0.001). sTAC was negatively associated with diastolic blood pressure (β = -8.458 ± 3.758, <i>p</i> = 0.026) in NW children and positively associated with insulin (β = 9.511 ± 3.107, <i>p</i> = 0.002) and the homeostatic model assessment of insulin resistance (β = 2.065 ± 0.680, <i>p</i> = 0.003) in OB children. SUA showed negative associations with total cholesterol (β = -4.062 ± 1.340, <i>p</i> = 0.003) and low-density lipoprotein cholesterol (β = -2.470 ± 1.190, <i>p</i> = 0.039) in NW children and high-density lipoprotein cholesterol (β = -1.306 ± 0.409, <i>p</i> &lt; 0.01) in OB children.</p> Conclusion <p>sTAC and SUA are positively associated and are increased in obesity. According to weight status, sTAC and SUA are associated with blood pressure, insulin resistance markers, and lipid profile.</p>

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Association of serum total antioxidant capacity and uric acid with obesity and cardiometabolic traits in Mexican children

  • 期刊论文

  • 发表日期：

    2025年7月26日

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  • Ana Nava-Cabrera,
  • Armando Ramírez-Cruz,
  • Araceli Pérez-Bautista,
  • Alan Canul-Ayil,
  • Gloria Chi-Díaz,
  • Elena Flores-Guillén,
  • Miguel Vazquez-Moreno,
  • Miguel Cruz

摘要

Background/objectives

Serum total antioxidant capacity (sTAC) and uric acid (SUA) levels have been related to oxidative stress in metabolic diseases. Nevertheless, the evidence in epidemiological studies is still scarce and inconsistent. We aimed to evaluate the association between sTAC, SUA, obesity, and cardiometabolic traits in Mexican children.

Subjects/methods

This cross-sectional study analyzed anthropometric data, blood pressure, cardiometabolic traits, and SUA levels of 248 children with normal weight (NW) and 255 with obesity (OB). sTAC was measured with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method.

Results

sTAC was directly related to SUA (β = 0.905 ± 0.358, p = 0.012). Obesity was positively associated with sTAC (β = 0.075 ± 0.020, p < 0.001) and SUA (β = 0.706 ± 0.129, p < 0.001). sTAC was negatively associated with diastolic blood pressure (β = -8.458 ± 3.758, p = 0.026) in NW children and positively associated with insulin (β = 9.511 ± 3.107, p = 0.002) and the homeostatic model assessment of insulin resistance (β = 2.065 ± 0.680, p = 0.003) in OB children. SUA showed negative associations with total cholesterol (β = -4.062 ± 1.340, p = 0.003) and low-density lipoprotein cholesterol (β = -2.470 ± 1.190, p = 0.039) in NW children and high-density lipoprotein cholesterol (β = -1.306 ± 0.409, p < 0.01) in OB children.

Conclusion

sTAC and SUA are positively associated and are increased in obesity. According to weight status, sTAC and SUA are associated with blood pressure, insulin resistance markers, and lipid profile.