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Background <p>Children with stunting are at risk of infections. We assessed the effect of lipid-based nutrient supplement (LNS) on morbidity in children with stunting.</p> Methods <p>This was a secondary analysis of a randomized, 2×2 factorial trial among 12–59 months-old, stunted children in Uganda. Children were randomized to LNS containing milk or soy protein and whey permeate or maltodextrin, or no supplementation, for 12 weeks. The outcomes were caregiver-reported morbidity after 2, 4, 8 and 12 weeks, serum C-reactive protein (S-CRP), α<sub>1</sub>-acid glycoprotein (S-AGP), and phase-angle (PhA) by bioimpedance.</p> Results <p>Of 750 children, mean (SD) age was 32.0 (11.7) months, 55% (<i>n</i> = 412) were male. LNS increased diarrhoea prevalence (18.1% vs 7.3%, <i>P</i> = 0.001) during the first two weeks, but not thereafter. There was no effect of LNS on cough or fever. LNS resulted in greater decline in S-AGP (−0.10 g/L, 95% CI: −0.17, −0.03, <i>P</i> = 0.003) but not S-CRP (25%, 95% CI: −11, 74, <i>P</i> = 0.193), and greater increase in PhA (0.10 degrees, 95% CI: 0.01, 0.18, <i>P</i> = 0.030), explained by greater fat-free mass. Milk compared to soy protein in LNS resulted in higher PhA (0.10 degrees, 95% CI: 0.02, 0.17, <i>P</i> = 0.013), not explained by fat-free mass.</p> Conclusion <p>LNS supplementation in children with stunting had no effect on morbidity but resulted in a small reduction in sub-acute systemic inflammation. The possible effect of LNS supplementation on inflammation in stunted children requires further evaluation. (<a href="http://www.isrctn.com">www.isrctn.com</a>: ISRCTN13093195).</p>

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Effect of lipid-based nutrient supplements on morbidity among children with stunting: secondary analysis of a randomized trial in Uganda

  • 期刊论文

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  • 发表日期：

    2025年3月31日

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  • Rolland Mutumba,
  • Joseph Mbabazi,
  • Hannah Pesu,
  • Jack I. Lewis,
  • Christian Mølgaard,
  • Christian Ritz,
  • Mette F. Olsen,
  • Andre Briend,
  • Nicolette Nabukeera-Barungi,
  • Jonathan C. Wells,
  • Henrik Friis,
  • Benedikte Grenov,
  • Ezekiel Mupere

摘要

Background

Children with stunting are at risk of infections. We assessed the effect of lipid-based nutrient supplement (LNS) on morbidity in children with stunting.

Methods

This was a secondary analysis of a randomized, 2×2 factorial trial among 12–59 months-old, stunted children in Uganda. Children were randomized to LNS containing milk or soy protein and whey permeate or maltodextrin, or no supplementation, for 12 weeks. The outcomes were caregiver-reported morbidity after 2, 4, 8 and 12 weeks, serum C-reactive protein (S-CRP), α1-acid glycoprotein (S-AGP), and phase-angle (PhA) by bioimpedance.

Results

Of 750 children, mean (SD) age was 32.0 (11.7) months, 55% (n = 412) were male. LNS increased diarrhoea prevalence (18.1% vs 7.3%, P = 0.001) during the first two weeks, but not thereafter. There was no effect of LNS on cough or fever. LNS resulted in greater decline in S-AGP (−0.10 g/L, 95% CI: −0.17, −0.03, P = 0.003) but not S-CRP (25%, 95% CI: −11, 74, P = 0.193), and greater increase in PhA (0.10 degrees, 95% CI: 0.01, 0.18, P = 0.030), explained by greater fat-free mass. Milk compared to soy protein in LNS resulted in higher PhA (0.10 degrees, 95% CI: 0.02, 0.17, P = 0.013), not explained by fat-free mass.

Conclusion

LNS supplementation in children with stunting had no effect on morbidity but resulted in a small reduction in sub-acute systemic inflammation. The possible effect of LNS supplementation on inflammation in stunted children requires further evaluation. (www.isrctn.com: ISRCTN13093195).