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<p>The global burden of diabetes is rising sharply, with a significant proportion of cases emerging in low- and middle-income countries (LMICs). Prediabetes, a condition characterized by elevated blood glucose levels that do not yet meet the threshold for diabetes, serves as a crucial stage for intervention and prevention. Despite its importance, comprehensive data on prediabetes prevalence in LMICs are sparse. Thus, we conducted a systematic review and meta-analysis to ascertain the prevalence of prediabetes in LMICs. We systematically reviewed studies on prediabetes in Low- and Middle-Income Countries (LMICs) from 1<sup>st</sup> January 2003 and 31<sup>st</sup> July 2024 using PubMed, Scopus, and Web of Science databases. The NIH study quality assessment tool assessed bias, and pooled prevalence was determined via a random-effects model. We examined publication bias through funnel plot analysis and Begg’s and Egger’s tests. The prevalence of prediabetes estimated from 164 studies conducted in LMICs was 13.1% (95% CI: 11.7%, 14.5%) based on the World Health Organization (WHO) criteria, and 27.0% (95% CI: 24.5%, 29.5%) based on the American Diabetes Association (ADA) criteria. The pooled prevalence did not significantly differ between males and females for both diagnostic criterias and by study design. The analysis indicated a noteworthy degree of heterogeneity in the pooled estimates (I2 &gt; 70%; <i>p</i> &lt; 0.05). The findings from this study indicated a higher burden of prediabetes within LMICs with regional variations.</p>

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The burden of prediabetes in low- and middle-income countries: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年2月19日

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  • Anjaly Joseph,
  • Christian Sewor,
  • Bhagiaswari Kodapally,
  • Chanda Engred Manda,
  • Jaison Joseph,
  • Elezebeth Mathews

摘要

The global burden of diabetes is rising sharply, with a significant proportion of cases emerging in low- and middle-income countries (LMICs). Prediabetes, a condition characterized by elevated blood glucose levels that do not yet meet the threshold for diabetes, serves as a crucial stage for intervention and prevention. Despite its importance, comprehensive data on prediabetes prevalence in LMICs are sparse. Thus, we conducted a systematic review and meta-analysis to ascertain the prevalence of prediabetes in LMICs. We systematically reviewed studies on prediabetes in Low- and Middle-Income Countries (LMICs) from 1st January 2003 and 31st July 2024 using PubMed, Scopus, and Web of Science databases. The NIH study quality assessment tool assessed bias, and pooled prevalence was determined via a random-effects model. We examined publication bias through funnel plot analysis and Begg’s and Egger’s tests. The prevalence of prediabetes estimated from 164 studies conducted in LMICs was 13.1% (95% CI: 11.7%, 14.5%) based on the World Health Organization (WHO) criteria, and 27.0% (95% CI: 24.5%, 29.5%) based on the American Diabetes Association (ADA) criteria. The pooled prevalence did not significantly differ between males and females for both diagnostic criterias and by study design. The analysis indicated a noteworthy degree of heterogeneity in the pooled estimates (I2 > 70%; p < 0.05). The findings from this study indicated a higher burden of prediabetes within LMICs with regional variations.