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<p>Two new agmatine derivatives, luteoagmacins A (<b>1</b>) and B (<b>2</b>), were isolated from the culture extract of the hot spring water-associated actinomycete <i>Luteococcus</i> sp. RD000023. The chemical structures of <b>1</b> and <b>2</b> were elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, and the structure of <b>2</b> was further confirmed by chemical synthesis. Based on disk diffusion and broth microdilution assays using the synthetic material, <b>2</b> exhibited broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeast.</p>

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Luteoagmacins A and B, new antimicrobial agmatine derivatives from a hot spring water-derived Luteococcus sp.

  • 期刊论文

  • 发表日期：

    2026年7月24日

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  • Shotaro Hoshino,
  • Emiko Nagai,
  • Hisayuki Komaki,
  • Shinta Ijichi,
  • Shumpei Asamizu,
  • Hiroyasu Onaka

摘要

Two new agmatine derivatives, luteoagmacins A (1) and B (2), were isolated from the culture extract of the hot spring water-associated actinomycete Luteococcus sp. RD000023. The chemical structures of 1 and 2 were elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, and the structure of 2 was further confirmed by chemical synthesis. Based on disk diffusion and broth microdilution assays using the synthetic material, 2 exhibited broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeast.