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<p>One new <i>α</i>-pyrone derivative, acremopyrone A (<b>1</b>) was isolated from the soil-derived fungus <i>Acremonium persicinum</i> 3.2858. The structure of <b>1</b> was elucidated by comprehensive spectroscopic analysis including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Compound <b>1</b> showed significant inhibitory activity against <i>α</i>-glucosidase. Enzyme kinetic analysis revealed a mixed-type mode of inhibition, which was further supported by molecular docking studies.</p>

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Discovery of new α-pyrone derivative with α-glucosidase inhibitory activity from the fungus Acremonium persicinum

  • 期刊论文

  • 发表日期：

    2026年7月15日

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  • Yu Tu,
  • Baodan Zhang,
  • Meiyan Bao,
  • Minhui Ji,
  • Ling Liu

摘要

One new α-pyrone derivative, acremopyrone A (1) was isolated from the soil-derived fungus Acremonium persicinum 3.2858. The structure of 1 was elucidated by comprehensive spectroscopic analysis including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Compound 1 showed significant inhibitory activity against α-glucosidase. Enzyme kinetic analysis revealed a mixed-type mode of inhibition, which was further supported by molecular docking studies.