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<p>A new aurodox-family compound named 2-methyl-10-hydroxy-A83016F (<b>1</b>) and the known aurodox (<b>2</b>) were isolated from the <i>Streptomyces</i> sp. HKIB0009; their structures were determined through comprehensive analysis of NMR and HRMS data. The antibacterial activities of these compounds against <i>Escherichia coli</i>, <i>Bacillus subtilis</i>, and <i>Staphylococcus aureu</i>s were evaluated using the broth microdilution method. The results showed that compound <b>1</b> exhibited weak antibacterial activity.</p>

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A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity

  • 期刊论文

  • 发表日期：

    2026年4月1日

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  • Xingtao Li,
  • Yuxin Sun,
  • Mimi Tian,
  • Linfang Tang,
  • Yuan Chen,
  • Zikang Zhao,
  • Mingming Cao,
  • Lijun Chen

摘要

A new aurodox-family compound named 2-methyl-10-hydroxy-A83016F (1) and the known aurodox (2) were isolated from the Streptomyces sp. HKIB0009; their structures were determined through comprehensive analysis of NMR and HRMS data. The antibacterial activities of these compounds against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus were evaluated using the broth microdilution method. The results showed that compound 1 exhibited weak antibacterial activity.