Scholarlink

<p>A new indole diketopiperazine penichrysogenone A (<b>1</b>), and two new natural products 4-(<i>N</i>-benzoyl-<i>N</i>-hydroxyamino)-butyric acid (<b>2</b>) and 2-acetamido-<i>N</i>-benzyl-2-(ethylamino)acetamide (<b>3</b>), together with 10 known compounds (<b>4</b>–<b>13</b>) were isolated from the fungus <i>Penicillium chrysogenum</i> wis54-1255. The structure of new compound was determined by the extensive spectroscopic analyses and ECD calculations. Bioactivity assays revealed that compound <b>4</b> showed antibacterial activity against <i>Pseudomonas solanacearum</i> (MIC = 64 μg/mL), while compound <b>10</b> exhibited antifungal activity against <i>Candida auris</i> (MIC = 32 μg/mL). Furthermore, compounds <b>2</b> and <b>10</b> displayed potent ABTS radical scavenging activity, superior to that of the positive control ascorbic acid.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

New indole diketopiperazine from the fungus Penicillium chrysogenum

  • 期刊论文

  • 发表日期：

    2025年11月27日

查看全文
  • Minhui Ji,
  • Qianqian Liu,
  • Ling Liu

摘要

A new indole diketopiperazine penichrysogenone A (1), and two new natural products 4-(N-benzoyl-N-hydroxyamino)-butyric acid (2) and 2-acetamido-N-benzyl-2-(ethylamino)acetamide (3), together with 10 known compounds (4–13) were isolated from the fungus Penicillium chrysogenum wis54-1255. The structure of new compound was determined by the extensive spectroscopic analyses and ECD calculations. Bioactivity assays revealed that compound 4 showed antibacterial activity against Pseudomonas solanacearum (MIC = 64 μg/mL), while compound 10 exhibited antifungal activity against Candida auris (MIC = 32 μg/mL). Furthermore, compounds 2 and 10 displayed potent ABTS radical scavenging activity, superior to that of the positive control ascorbic acid.