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<p>Two previously unreported compounds, designated pyrrole-2, 5-dione xylogonone acids A (<b>1</b>) and B (<b>2</b>), were isolated from the ascomycete fungus <i>Xylogone Sphaerospora</i>. These metabolites feature a rare, highly functionalized pyrrole-2,5-dione. Their chemical structures were determined through detailed analysis of NMR and HRMS data, with the structure of compound <b>1</b> further validated by X-ray crystallographic analysis. Both compounds exhibited distinct cytotoxic profiles against several human cancer cell lines, including A549, MDA-MB-231, HepG2, HT-29, K562, and SW620, with IC<sub>50</sub> values ranging from 3.76 to 72.43 µM for compound <b>1</b> and 7.97 to 68.46 µM for compound <b>2</b>.</p>

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Two novel cytotoxic pyrrole-2,5-dione xylogonone acids A and B isolated from the fungus Xylogone Sphaerospora

  • 期刊论文

  • 发表日期：

    2025年10月6日

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  • Xiao Ren,
  • Pengran Cao,
  • Jingtong Zhu,
  • Yeying Li,
  • Xiaolan Cui,
  • Tengyu Wang,
  • Jiawang Li,
  • Wenbin Shen,
  • Xuexia Zhang,
  • Lijie Wang,
  • Xinhua Lu

摘要

Two previously unreported compounds, designated pyrrole-2, 5-dione xylogonone acids A (1) and B (2), were isolated from the ascomycete fungus Xylogone Sphaerospora. These metabolites feature a rare, highly functionalized pyrrole-2,5-dione. Their chemical structures were determined through detailed analysis of NMR and HRMS data, with the structure of compound 1 further validated by X-ray crystallographic analysis. Both compounds exhibited distinct cytotoxic profiles against several human cancer cell lines, including A549, MDA-MB-231, HepG2, HT-29, K562, and SW620, with IC50 values ranging from 3.76 to 72.43 µM for compound 1 and 7.97 to 68.46 µM for compound 2.