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<p>Linfuranone F (<b>1</b>), a new furanone-containing polyketide, was isolated from the culture extract of an actinomycete of the genus <i>Sphaerimonospora</i> along with three known linfuranones B (<b>2</b>), C (<b>3</b>), and D (<b>4</b>). Compound <b>1</b> was established as a 6,7-dehydrated congener of <b>3</b> by comparing their spectroscopic data and considering their biosynthetic relatedness. All compounds displayed agonistic activity against PPARγ in a reporter gene assay and <b>1</b> showed the highest activity.</p>

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Linfuranone F, a PPARγ-agonistic furanone-containing polyketide, from a rare actinomycete Sphaerimonospora sp.

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Desy Wulan Triningsih,
  • Nobuyasu Matsuura,
  • Hisayuki Komaki,
  • Enjuro Harunari,
  • Yasuhiro Igarashi

摘要

Linfuranone F (1), a new furanone-containing polyketide, was isolated from the culture extract of an actinomycete of the genus Sphaerimonospora along with three known linfuranones B (2), C (3), and D (4). Compound 1 was established as a 6,7-dehydrated congener of 3 by comparing their spectroscopic data and considering their biosynthetic relatedness. All compounds displayed agonistic activity against PPARγ in a reporter gene assay and 1 showed the highest activity.