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<p>A new glycosylated derivative of rausuquinone, rausuquinonoside (<b>1</b>), was isolated from the Tai Lake sediment-derived actinomycete, <i>Streptomyces</i> sp. HU061-2. The structure of <b>1</b> was determined by 1D, 2D NMR, MS spectral analysis and the comparison with data from the literature. Bioassay test showed that <b>1</b> exhibited potent cytotoxic activity against tumor cell lines HepG2, HCT116 and A549.</p>

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A new glycosylated derivative of rausuquinone with cytotoxic activity from Streptomyces sp. HU061-2

  • 期刊论文

  • 发表日期：

    2025年8月19日

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  • Ping-Ting Qian,
  • Zhen-Yu Wang,
  • Xiao-He Jia,
  • Zheng-Ping Zhou,
  • Shao-Yong Zhang,
  • Huan Qi,
  • Ji-Dong Wang,
  • Hui Zhang

摘要

A new glycosylated derivative of rausuquinone, rausuquinonoside (1), was isolated from the Tai Lake sediment-derived actinomycete, Streptomyces sp. HU061-2. The structure of 1 was determined by 1D, 2D NMR, MS spectral analysis and the comparison with data from the literature. Bioassay test showed that 1 exhibited potent cytotoxic activity against tumor cell lines HepG2, HCT116 and A549.