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<p>Chemical studies of <i>Gandjariella</i> species from geothermal soil led to the isolation of three new glycosylated anthracyclines, mutactimycins H−J (<b>1</b>−<b>3</b>), along with known mutactimycin E (<b>4</b>). The structures of <b>1</b>−<b>3</b> were elucidated by combination of spectroscopic analyses and chemical degradation. Compounds <b>1</b>−<b>4</b> exhibited antibacterial activity against four <i>Mycobacterium</i> species with MIC values ranging from 3.13 to 50 μg mL<sup>−1</sup>.</p>

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Mutactimycins H–J, antimycobacterial anthracyclines, from a thermophilic actinomycete of the genus Gandjariella

  • 期刊论文

  • 发表日期：

    2025年8月15日

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  • Desy Wulan Triningsih,
  • Satsuki Kimachi,
  • Fitria Ningsih,
  • Wellyzar Sjamsuridzal,
  • Satoru Shigeno,
  • Elyza Aiman Azizah Nur,
  • Taichi Ohshiro,
  • Yasuhiro Igarashi

摘要

Chemical studies of Gandjariella species from geothermal soil led to the isolation of three new glycosylated anthracyclines, mutactimycins H−J (1−3), along with known mutactimycin E (4). The structures of 1−3 were elucidated by combination of spectroscopic analyses and chemical degradation. Compounds 1−4 exhibited antibacterial activity against four Mycobacterium species with MIC values ranging from 3.13 to 50 μg mL−1.