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<p>Emericellopsic acid (<b>1</b>), the first B/C ring-rearranged fusidane-type antibiotic possessing a 6/5/7/5-fused ring framework, together with seven known helvolic acid derivatives, was isolated from the sponge-associated fungus <i>Emericellopsis maritima</i> IMB18-123 cultivated with autoclaved <i>Pseudomonas aeruginosa</i>. The structure of <b>1</b> was determined by extensive spectroscopic data analysis combined with ECD calculation. Compound <b>1</b> exhibited moderate antimicrobial activities against <i>Staphylococcus aureus</i> and <i>S. epidermidis</i> with the minimum inhibition concentration of 4−8 μg ml<sup>−1</sup>.</p>

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Emericellopsic acid, a helvolic acid derivative with a 6/5/7/5 tetracyclic skeleton from sponge-derived Emericellopsis maritima

  • 期刊论文

  • 发表日期：

    2025年7月29日

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  • Shasha Li,
  • Xiaomeng Hao,
  • Yan Li,
  • Maoluo Gan

摘要

Emericellopsic acid (1), the first B/C ring-rearranged fusidane-type antibiotic possessing a 6/5/7/5-fused ring framework, together with seven known helvolic acid derivatives, was isolated from the sponge-associated fungus Emericellopsis maritima IMB18-123 cultivated with autoclaved Pseudomonas aeruginosa. The structure of 1 was determined by extensive spectroscopic data analysis combined with ECD calculation. Compound 1 exhibited moderate antimicrobial activities against Staphylococcus aureus and S. epidermidis with the minimum inhibition concentration of 4−8 μg ml−1.