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<p>Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites produced by them. Two new molecules designated amino-naphthoic acid derivatives (<b>1</b> and <b>2</b>) were obtained by biological transformation using the deep-sea derived bacterium <i>Serinicoccus marinus</i> KDM482 successfully. Structural analysis using 1D and 2D NMR and MS data revealed that both <b>1</b> and <b>2</b> were dimerized compounds of 3-amino-2-naphthoic acid. In biological assays, <b>1</b> and <b>2</b> moderately inhibited the growth of Malme-3M cells.</p>

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New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium Serinicoccus marinus KDM482

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Mai Sakaguchi,
  • Katsuki Kikuchi,
  • Ryota Okamura,
  • Akito Taniguchi,
  • Kenichiro Nagai,
  • Reiko Seki,
  • Masashi Ando,
  • Teruyoshi Tanaka,
  • Takashi Fukuda

摘要

Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites produced by them. Two new molecules designated amino-naphthoic acid derivatives (1 and 2) were obtained by biological transformation using the deep-sea derived bacterium Serinicoccus marinus KDM482 successfully. Structural analysis using 1D and 2D NMR and MS data revealed that both 1 and 2 were dimerized compounds of 3-amino-2-naphthoic acid. In biological assays, 1 and 2 moderately inhibited the growth of Malme-3M cells.