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<p>Two new butanolides asperbutanolides A (<b>1</b>) and B (<b>2</b>), and a new fatty acid derivative omphalotol C (<b>3</b>), along with 5 known compounds were isolated from the ethyl acetate (EtOAc) crude extract of the deep-sea-derived fungus <i>Aspergillus tabacinus</i> LW82 guided by OSMAC (One Strain Many Compounds) strategy. The structural elucidation and absolute configuration determination of these compounds were achieved by comprehensive spectroscopic analysis, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and [Rh<sub>2</sub>(OCOCF<sub>3</sub>)<sub>4</sub>]-induced electronic circular dichroism (ECD) experiment. Compound <b>1</b> exhibited antibacterial activity against <i>Pseudomonas syringae</i> pv. <i>Lachrymans</i> with MIC value of 64 μg ml<sup>−1</sup>. Furthermore, compound <b>6</b> displayed significant antifungal efficacy against <i>Cryptococcus gattii</i> R265 and 3284G14, with both MIC values of 8 μg ml<sup>−1</sup>, comparable to the antifungal agent fluconazole.</p>

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New antimicrobial butanolides from a deep sea-derived fungus Aspergillus tabacinus LW82

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Yu Tu,
  • Jinxin Zhang,
  • Lei Cai,
  • Ling Liu

摘要

Two new butanolides asperbutanolides A (1) and B (2), and a new fatty acid derivative omphalotol C (3), along with 5 known compounds were isolated from the ethyl acetate (EtOAc) crude extract of the deep-sea-derived fungus Aspergillus tabacinus LW82 guided by OSMAC (One Strain Many Compounds) strategy. The structural elucidation and absolute configuration determination of these compounds were achieved by comprehensive spectroscopic analysis, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiment. Compound 1 exhibited antibacterial activity against Pseudomonas syringae pv. Lachrymans with MIC value of 64 μg ml−1. Furthermore, compound 6 displayed significant antifungal efficacy against Cryptococcus gattii R265 and 3284G14, with both MIC values of 8 μg ml−1, comparable to the antifungal agent fluconazole.