Scholarlink

<p>A new cyclic tetrapeptide named Cereusitin B (<b>1</b>), along with a number of known cyclic dipeptides was isolated from the fermentation broth of a marine-associated <i>Bacillus</i> sp. I-2. The structure of Cereusitin B, cyclo-(<span>l</span>-phenylalanyl-trans-4-hydroxy-<span>l</span>-prolyl-<span>l</span>-leucyl-<span>l</span>-alanine), was determined through extensive analysis using high-resolution electrospray ionization mass spectrometry and NMR spectral data (1D, 2D NMR), and its identity was further confirmed by Marfey’ method and chemical synthesis. The antimicrobial activity tests showed that compound <b>2</b> was moderately active against <i>Candida albicans</i> with a MIC value of 125 µg mL<sup>−1</sup>, while the other compounds exhibited no antimicrobial activity at the experimental concentrations. In addition, compound <b>1</b> showed the ability to inhibit the formation of <i>S. aureus</i> biofilm.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Isolation and synthesis of a new cyclic tetrapeptide from marine-associated Bacillus sp. and its bacterial biofilm formation inhibitory activity

  • 期刊论文

  • 发表日期：

    2025年5月19日

查看全文
  • Shuaiqi Ma,
  • Shixin Li,
  • Li Song,
  • Asma Riaz,
  • Ruifeng Huang,
  • Shaofen Zhou,
  • Jingnan Qiu,
  • Zonglin Chu,
  • Jian He

摘要

A new cyclic tetrapeptide named Cereusitin B (1), along with a number of known cyclic dipeptides was isolated from the fermentation broth of a marine-associated Bacillus sp. I-2. The structure of Cereusitin B, cyclo-(l-phenylalanyl-trans-4-hydroxy-l-prolyl-l-leucyl-l-alanine), was determined through extensive analysis using high-resolution electrospray ionization mass spectrometry and NMR spectral data (1D, 2D NMR), and its identity was further confirmed by Marfey’ method and chemical synthesis. The antimicrobial activity tests showed that compound 2 was moderately active against Candida albicans with a MIC value of 125 µg mL−1, while the other compounds exhibited no antimicrobial activity at the experimental concentrations. In addition, compound 1 showed the ability to inhibit the formation of S. aureus biofilm.