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<p>Targeting drug-resistant <i>Acinetobacter baumannii</i>, two fungal strains, <i>Epicoccum</i> sp. 1-042 and <i>Penicillium</i> sp. 19-115, were identified from 35 fungi isolated from Tibet. Bioassay-guided isolation from <i>Epicoccum</i> sp. 1-042 yielded a novel cyclohexenone, epiconone (<b>1</b>), and parasitenone (<b>2</b>), while patulin (<b>3</b>) was isolated from <i>Penicillium</i> sp. 19-115. Structural elucidation was accomplished through comprehensive spectroscopic analysis and quantum chemistry calculations. The biosynthetic pathways of compounds <b>1</b> and <b>2</b> were proposed based on bioinformatics analysis. Compounds <b>1</b> − <b>3</b> exhibited antibacterial activity against carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) with MIC values ranging from 4 to 128 <i>μ</i>g mL<sup>-1</sup>.</p>

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Epiconone, one novel cyclohexenone from endophytic fungi Epicoccum sp. 1-042

  • 期刊论文

  • 发表日期：

    2025年3月7日

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  • Shanshan Chang,
  • Xinyue Huang,
  • Meng Liu,
  • Ning He,
  • Yan Li,
  • Hu Li,
  • Yihong Li,
  • Mengna Luo,
  • Mengyuan Wang,
  • Xichi Hu,
  • Yunying Xie

摘要

Targeting drug-resistant Acinetobacter baumannii, two fungal strains, Epicoccum sp. 1-042 and Penicillium sp. 19-115, were identified from 35 fungi isolated from Tibet. Bioassay-guided isolation from Epicoccum sp. 1-042 yielded a novel cyclohexenone, epiconone (1), and parasitenone (2), while patulin (3) was isolated from Penicillium sp. 19-115. Structural elucidation was accomplished through comprehensive spectroscopic analysis and quantum chemistry calculations. The biosynthetic pathways of compounds 1 and 2 were proposed based on bioinformatics analysis. Compounds 1 − 3 exhibited antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB) with MIC values ranging from 4 to 128 μg mL-1.