A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

期刊论文
发表日期：

2024年5月15日

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Yuta Awano,
Ryoya Ishii,
Yume Takahashi,
Hayama Tsutsumi,
Yoshihiro Watanabe,
Masaaki Sonoda,
Rei Hokari,
Masato Iwatsuki,
Yuki Inahashi

摘要

A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.