Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima

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发表日期：

2024年5月9日

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Somporn Palasarn,
Kitlada Srichomthong,
Tuksaporn Thummarukcharoen,
Chawanee Thongpanchang,
Masahiko Isaka

摘要

Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC₅₀ values of 0.12 and 0.21 μM, respectively.