New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292

期刊论文
发表日期：

2024年3月4日

查看全文

So-ichiro Kimura,
Yoshihiro Watanabe,
Shiori Shibasaki,
Naoya Shinzato,
Yuki Inahashi,
Toshiaki Sunazuka,
Rei Hokari,
Aki Ishiyama,
Masato Iwatsuki

摘要

Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured material of Streptomyces sp. RBL-0292 isolated from the soil on Hamahiga Island in Okinawa prefecture. The structures of 1 and 2 were elucidated as new iromycin analogs having α-pyridone ring by MS and NMR analyses. Compounds 1 and 2 showed moderate in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC₅₀ values ranging from 80.7 to 106.7 µM.