Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058

期刊论文
发表日期：

2024年2月2日

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So-ichiro Kimura,
Yoshihiro Watanabe,
Yudai Mikasa,
Rei Miyano,
Toshiyuki Tokiwa,
Kenichi Nonaka,
Takuji Nakashima,
Yoshihiko Noguchi,
Tomoyasu Hirose,
Toshiaki Sunazuka,
Rei Hokari,
Aki Ishiyama,
Masato Iwatsuki

摘要

Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.