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<p>Chirality governs not only local static molecular structures but also dynamic conformational changes and communication between interacting components. This review presents a unified theoretical framework for twisted host–guest systems that explicitly incorporates right- and left- (<i>P</i>- and <i>M</i>-) asymmetry to describe nonlinear chiroptical phenomena. The concept is extended from a single twisted host to multiple twisted hosts, wherein three cooperative interplays (host–host, guest–guest, and host–guest) collectively give rise to not only conventional amplification of asymmetry but also a qualitatively distinct regime, referred to here as superamplification. By bridging molecular host–guest equilibria and polymeric helicity through a common cooperative framework, this review establishes a theoretical basis for understanding how local chiral bias evolves into macroscopic superamplification of asymmetry, with particular emphasis on elucidating the origin and mechanism of this remarkable nonlinear phenomenon that has long been experimentally recognized but is conceptually elusive.</p>

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Twist, bind, and amplify: Mechanistic pathways toward the superamplification of asymmetry in host–guest systems

  • 期刊论文

  • 发表日期：

    2026年4月22日

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  • Nozomu Suzuki,
  • Shuhei Koike

摘要

Chirality governs not only local static molecular structures but also dynamic conformational changes and communication between interacting components. This review presents a unified theoretical framework for twisted host–guest systems that explicitly incorporates right- and left- (P- and M-) asymmetry to describe nonlinear chiroptical phenomena. The concept is extended from a single twisted host to multiple twisted hosts, wherein three cooperative interplays (host–host, guest–guest, and host–guest) collectively give rise to not only conventional amplification of asymmetry but also a qualitatively distinct regime, referred to here as superamplification. By bridging molecular host–guest equilibria and polymeric helicity through a common cooperative framework, this review establishes a theoretical basis for understanding how local chiral bias evolves into macroscopic superamplification of asymmetry, with particular emphasis on elucidating the origin and mechanism of this remarkable nonlinear phenomenon that has long been experimentally recognized but is conceptually elusive.