Scholarlink

<p>Monodisperse poly(acrylic acid) (PAA) nanoparticles were synthesized via precipitation polymerization. Markedly high loading of the anticancer drug doxorubicin hydrochloride (DOX) was achieved, with drug contents reaching approximately 44 wt%, which exceeds the values typically reported for polymer-based nanocarriers. Structural analyses using transmission electron microscopy and small-angle X-ray scattering (SAXS) revealed that the encapsulated DOX was not distributed uniformly but instead formed a distinct core-localized DOX-rich domain while maintaining the spherical morphology of the PAA nanoparticles. Notably, each PAA nanoparticle typically contained a single DOX-rich domain, and morphologies with multiple domains were rarely observed, indicating a single-domain nucleation and growth mechanism. Quantitative single-particle fluorescence analysis further demonstrated that the proportion of DOX-loaded particles increased systematically with increasing drug loading, reaching 75.8% at 44 wt%, which was consistent with the results of the SAXS analysis. In addition, the PAA nanoparticles exhibited strong and stable affinity toward hydroxyapatite, underscoring their potential for bone-targeted drug delivery. Collectively, these findings establish PAA nanoparticles as robust, high-capacity carriers with unique structural features and bone affinity, offering a promising platform for advanced drug delivery systems, particularly in the treatment of metastatic cancers.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Polyacrylic acid nanoparticles encapsulating doxorubicin: structural analysis and encapsulation mechanism

  • 期刊论文

  • 发表日期：

    2026年1月9日

查看全文
  • Takuma Kojima,
  • Shin Takano,
  • Kazuo Sakurai

摘要

Monodisperse poly(acrylic acid) (PAA) nanoparticles were synthesized via precipitation polymerization. Markedly high loading of the anticancer drug doxorubicin hydrochloride (DOX) was achieved, with drug contents reaching approximately 44 wt%, which exceeds the values typically reported for polymer-based nanocarriers. Structural analyses using transmission electron microscopy and small-angle X-ray scattering (SAXS) revealed that the encapsulated DOX was not distributed uniformly but instead formed a distinct core-localized DOX-rich domain while maintaining the spherical morphology of the PAA nanoparticles. Notably, each PAA nanoparticle typically contained a single DOX-rich domain, and morphologies with multiple domains were rarely observed, indicating a single-domain nucleation and growth mechanism. Quantitative single-particle fluorescence analysis further demonstrated that the proportion of DOX-loaded particles increased systematically with increasing drug loading, reaching 75.8% at 44 wt%, which was consistent with the results of the SAXS analysis. In addition, the PAA nanoparticles exhibited strong and stable affinity toward hydroxyapatite, underscoring their potential for bone-targeted drug delivery. Collectively, these findings establish PAA nanoparticles as robust, high-capacity carriers with unique structural features and bone affinity, offering a promising platform for advanced drug delivery systems, particularly in the treatment of metastatic cancers.