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<p>Medical devices are indispensable in modern medicine for saving patients with injuries or illnesses and improving their quality of life. The development of polymers that elicit minimal biological reactions upon contact with tissues or biological components is critical for the safe and effective use of these devices. 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers, invented in Japan, represent a milestone in bioinspired materials science because they have been designed to mimic the phosphorylcholine groups naturally present on cell membranes, endowing them with excellent biocompatibility and resistance to nonspecific protein adsorption. Diverse MPC polymer architectures have been synthesized to optimize functional expression and tailor surface properties. Moreover, molecular designs have enabled the modification of conventional polymers, metals, and ceramics, thereby expanding their utility in diverse biomedical applications. This review highlights the molecular design concept, interfacial properties, and current status of MPC polymers as highly reliable surface treatment materials and summarizes their broad implementation in medical devices.</p>

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Invention and global impact of bioinspired 2-methacryloyloxyethyl phosphorylcholine polymers: molecular design, functions, and implementation in medical devices

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Kazuhiko Ishihara

摘要

Medical devices are indispensable in modern medicine for saving patients with injuries or illnesses and improving their quality of life. The development of polymers that elicit minimal biological reactions upon contact with tissues or biological components is critical for the safe and effective use of these devices. 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers, invented in Japan, represent a milestone in bioinspired materials science because they have been designed to mimic the phosphorylcholine groups naturally present on cell membranes, endowing them with excellent biocompatibility and resistance to nonspecific protein adsorption. Diverse MPC polymer architectures have been synthesized to optimize functional expression and tailor surface properties. Moreover, molecular designs have enabled the modification of conventional polymers, metals, and ceramics, thereby expanding their utility in diverse biomedical applications. This review highlights the molecular design concept, interfacial properties, and current status of MPC polymers as highly reliable surface treatment materials and summarizes their broad implementation in medical devices.