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<p>Mucin is a biological compound that consists of high-molecular-weight glycoproteins and plays an important role in the evaporation of water from respiratory droplets. Accurate characterization of the molecular structure of mucin in aqueous solution was performed using light scattering measurements. The molecular weight, <i>M</i> = 2.92 × 10<sup>7</sup>, and the radius of gyration, <i>R</i><sub>g</sub> = 289 nm, were determined from static light scattering, and the hydrodynamic radius, <i>R</i><sub>h</sub> = 198 nm, was determined from dynamic light scattering. The <i>R</i><sub>g</sub>/<i>R</i><sub>h</sub> ratio of 1.46 and the observed particle scattering function reveal that the molecular structure of mucin is elongated rather than spherical. As the size of molecules approaches the wavelength of the detected light, the analysis of light scattering measurements requires careful consideration. The calculation method devised by H. Fujita enables measurement of the molecular structure with extremely high accuracy.</p>

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Structural characterization of mucin in aqueous solution by static and dynamic light scattering measurements

  • 期刊论文

  • 发表日期：

    2025年8月25日

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  • Kayori Takahashi,
  • Kenjiro Iida,
  • Hiromu Sakurai,
  • Nobuyuki Takegawa

摘要

Mucin is a biological compound that consists of high-molecular-weight glycoproteins and plays an important role in the evaporation of water from respiratory droplets. Accurate characterization of the molecular structure of mucin in aqueous solution was performed using light scattering measurements. The molecular weight, M = 2.92 × 107, and the radius of gyration, Rg = 289 nm, were determined from static light scattering, and the hydrodynamic radius, Rh = 198 nm, was determined from dynamic light scattering. The Rg/Rh ratio of 1.46 and the observed particle scattering function reveal that the molecular structure of mucin is elongated rather than spherical. As the size of molecules approaches the wavelength of the detected light, the analysis of light scattering measurements requires careful consideration. The calculation method devised by H. Fujita enables measurement of the molecular structure with extremely high accuracy.