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<p>An artificial kidney is a medical device used in dialysis treatment for patients with renal failure. Owing to its prolonged contact with blood, artificial kidneys must have excellent antithrombogenic properties. An artificial kidney contains approximately 10,000 porous hollow fiber membranes, which remove water and uremic toxins from the blood through the principles of dialysis and filtration. It is well known that hollow fiber membranes made from polysulfone-based polymers (PSf) and polyvinylpyrrolidone (PVP) have high removal performance, accounting for 90% of the global market share. PVP, a hydrophilic polymer, contributes to the expression of antithrombogenic properties. However, complications due to insufficient antithrombogenic properties remain a challenge, and there has been strong demand for further improvements in antithrombogenic properties. We succeeded in commercializing PSf membrane artificial kidneys containing antithrombogenic polymers other than PVP for the first time by focusing on the mobility of adsorbed water. Furthermore, advanced analysis made it possible to design antithrombogenic polymers driven by computational science. This review discusses the design of antithrombogenic polymers based on the mobility of water and the commercialization of antithrombogenic artificial kidneys.</p>

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Design of antithrombogenic polymers based on their interactions with water and commercialization of artificial kidneys

  • 期刊论文

  • 发表日期：

    2025年10月22日

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  • Yoshiyuki Ueno,
  • Masaki Fujita,
  • Hiroyuki Sugaya,
  • Takeshi Baba,
  • Masaru Nakada

摘要

An artificial kidney is a medical device used in dialysis treatment for patients with renal failure. Owing to its prolonged contact with blood, artificial kidneys must have excellent antithrombogenic properties. An artificial kidney contains approximately 10,000 porous hollow fiber membranes, which remove water and uremic toxins from the blood through the principles of dialysis and filtration. It is well known that hollow fiber membranes made from polysulfone-based polymers (PSf) and polyvinylpyrrolidone (PVP) have high removal performance, accounting for 90% of the global market share. PVP, a hydrophilic polymer, contributes to the expression of antithrombogenic properties. However, complications due to insufficient antithrombogenic properties remain a challenge, and there has been strong demand for further improvements in antithrombogenic properties. We succeeded in commercializing PSf membrane artificial kidneys containing antithrombogenic polymers other than PVP for the first time by focusing on the mobility of adsorbed water. Furthermore, advanced analysis made it possible to design antithrombogenic polymers driven by computational science. This review discusses the design of antithrombogenic polymers based on the mobility of water and the commercialization of antithrombogenic artificial kidneys.