Scholarlink

<p>Breast cancer, the most common cancer diagnosed among women worldwide, remains a significant clinical challenge due to its molecular heterogeneity and the development of resistance to conventional therapies. This study investigates the potential of silodosin, an α1A-adrenergic receptor (AR) antagonist, as a novel therapeutic agent in breast cancer, an area where its use has not been previously explored. Through detailed in vitro and in silico analyses, we elucidate the complex molecular mechanisms behind silodosin’s antitumor effects. We demonstrate its ability to inhibit cell proliferation, induce apoptosis, reduce migration, and prevent 3D spheroid formation. Importantly, these effects are observed across different breast cancer subtypes. Crucially, our integrated approach reveals that silodosin’s mechanism is not solely dependent on α1A-AR blockade. Molecular docking studies strongly suggest that silodosin directly interacts with both isoforms of the estrogen receptor (ERα and ERβ) with high affinity, binding to key residues within the ligand-binding domains of these receptors. This points to a new, dual-targeting mechanism of action. While its known α1A-AR antagonism may contribute to its effects, silodosin could also act as an ER ligand, modulating estrogen-driven pathways essential in breast cancer development. This study provides the first experimental and computational evidence supporting the repurposing of silodosin as a potential multi-targeted therapeutic agent for breast cancer, opening promising new opportunities for patients with limited treatment options and encouraging further preclinical and clinical studies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Molecular insights into Silodosin’s anti-cancer effects: a promising repurposing strategy for breast cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月5日

查看全文
  • Michele Pellegrino,
  • Maria Antonietta Occhiuzzi,
  • Maria Marra,
  • Francesca Giordano,
  • Fedora Grande,
  • Stefano Aquaro,
  • Stefania Marsico,
  • Paola Tucci

摘要

Breast cancer, the most common cancer diagnosed among women worldwide, remains a significant clinical challenge due to its molecular heterogeneity and the development of resistance to conventional therapies. This study investigates the potential of silodosin, an α1A-adrenergic receptor (AR) antagonist, as a novel therapeutic agent in breast cancer, an area where its use has not been previously explored. Through detailed in vitro and in silico analyses, we elucidate the complex molecular mechanisms behind silodosin’s antitumor effects. We demonstrate its ability to inhibit cell proliferation, induce apoptosis, reduce migration, and prevent 3D spheroid formation. Importantly, these effects are observed across different breast cancer subtypes. Crucially, our integrated approach reveals that silodosin’s mechanism is not solely dependent on α1A-AR blockade. Molecular docking studies strongly suggest that silodosin directly interacts with both isoforms of the estrogen receptor (ERα and ERβ) with high affinity, binding to key residues within the ligand-binding domains of these receptors. This points to a new, dual-targeting mechanism of action. While its known α1A-AR antagonism may contribute to its effects, silodosin could also act as an ER ligand, modulating estrogen-driven pathways essential in breast cancer development. This study provides the first experimental and computational evidence supporting the repurposing of silodosin as a potential multi-targeted therapeutic agent for breast cancer, opening promising new opportunities for patients with limited treatment options and encouraging further preclinical and clinical studies.