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<p>L-Tetrahydropalmatine (L-THP) is an isoquinoline alkaloid derived from the traditional Chinese herb Corydalis (<i>genus Corydalis</i>), particularly its analgesic and sedative effects. The in-depth function of L-THP on gastric cancer (GC) immune escape is still unclear. Here, the present research aimed to investigate the function of L-THP on GC antitumor response. Results indicated that L-THP promoted the cytotoxicity and antitumor response of CD8<sup>+</sup> T cells to GC cells. Moreover, L-THP up-regulated the ferroptosis of GC cells. Mechanistically, L-THP recognized the FSP1 protein and bound to FSP1 with high binding affinity. L-THP reduced the FSP1 stability to trigger the ferroptosis of GC cells. In conclusion, this study shows that L-THP synergizes cytotoxic CD8<sup>+</sup> T cell-mediated GC antitumor response and ferroptosis through FSP1, providing potent evidence for GC immunoregulation.</p>

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L-Tetrahydropalmatine synergizes cytotoxic CD8+ T mediated antitumor and ferroptosis in gastric cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月24日

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  • Le Zhou,
  • Yaqin Wei,
  • Kai Lin,
  • Yu Lu

摘要

L-Tetrahydropalmatine (L-THP) is an isoquinoline alkaloid derived from the traditional Chinese herb Corydalis (genus Corydalis), particularly its analgesic and sedative effects. The in-depth function of L-THP on gastric cancer (GC) immune escape is still unclear. Here, the present research aimed to investigate the function of L-THP on GC antitumor response. Results indicated that L-THP promoted the cytotoxicity and antitumor response of CD8+ T cells to GC cells. Moreover, L-THP up-regulated the ferroptosis of GC cells. Mechanistically, L-THP recognized the FSP1 protein and bound to FSP1 with high binding affinity. L-THP reduced the FSP1 stability to trigger the ferroptosis of GC cells. In conclusion, this study shows that L-THP synergizes cytotoxic CD8+ T cell-mediated GC antitumor response and ferroptosis through FSP1, providing potent evidence for GC immunoregulation.