Scholarlink

<p>Colorectal cancer (CRC) represents a significant global health burden, contributing significantly to cancer-related mortality. The underlying genetic and metabolic underpinnings of CRC remain incompletely understood. In this study, we conducted a comprehensive investigation into metabolic perturbations in 29 CRC patients utilizing targeted omics approaches, compared to public databases. Additionally, we examined serum and tissue samples from 12 patients, with and without preoperative glucose challenge, using targeted metabolomics to investigate glucose and fructose metabolism. Notably, elevated levels of serum <span>D</span>-Fructose and <span>L</span>-Lactic acid following glucose administration indicate augmented glycolytic activity and polyol pathway-mediated glucose conversion (to fructose). Despite variations in tumor responses, our results underscore the potential significance of fructose metabolism in CRC progression, shedding light on therapeutic avenues targeting the Warburg effect. This research lays a solid foundation for future translational research into metabolic interventions in CRC treatment and enhances our understanding of cancer-related metabolic reprogramming.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evidence of fructose metabolism in colorectal cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月16日

查看全文
  • Giuseppe Sigismondo Sica,
  • Julia Bischof,
  • Lukas Funke,
  • Juhl Hartmut,
  • Eleonora Candi,
  • Alessandro Mauriello,
  • Manuel Scimeca,
  • Xinyue Gao,
  • Luca Savino,
  • Francesca Servadei,
  • Ruigang Yang,
  • Lu Wang,
  • Qing Zhao,
  • Wen-Lian Chen,
  • Qiang Sun,
  • Wei Jia,
  • Gerry Melino

摘要

Colorectal cancer (CRC) represents a significant global health burden, contributing significantly to cancer-related mortality. The underlying genetic and metabolic underpinnings of CRC remain incompletely understood. In this study, we conducted a comprehensive investigation into metabolic perturbations in 29 CRC patients utilizing targeted omics approaches, compared to public databases. Additionally, we examined serum and tissue samples from 12 patients, with and without preoperative glucose challenge, using targeted metabolomics to investigate glucose and fructose metabolism. Notably, elevated levels of serum D-Fructose and L-Lactic acid following glucose administration indicate augmented glycolytic activity and polyol pathway-mediated glucose conversion (to fructose). Despite variations in tumor responses, our results underscore the potential significance of fructose metabolism in CRC progression, shedding light on therapeutic avenues targeting the Warburg effect. This research lays a solid foundation for future translational research into metabolic interventions in CRC treatment and enhances our understanding of cancer-related metabolic reprogramming.