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<p>The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.</p>

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The role and clinical value of natriuretic peptide receptor family in malignant tumor

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月28日

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  • Chuqi Quan,
  • Weilin Shao,
  • Yihao Yang,
  • Qian Yao,
  • Zuozhang Yang,
  • Zhihong Yao

摘要

The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.