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<p>The lethal effect of injection of the endotoxin, lipopolysaccharide, as a surrogate for sepsis, is known to require both Caspase-8 and Caspase-11 in mice. In this issue, Liu et al. provide compelling evidence that the cleavage of the de-ubiquitinase CYLD by Caspase-8 is required for Caspase-11 expression, thus providing the “missing link” for the role of Caspase-8 in endotoxicity.</p>

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Caspase-8 comes in from the CYLD

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Douglas R. Green

摘要

The lethal effect of injection of the endotoxin, lipopolysaccharide, as a surrogate for sepsis, is known to require both Caspase-8 and Caspase-11 in mice. In this issue, Liu et al. provide compelling evidence that the cleavage of the de-ubiquitinase CYLD by Caspase-8 is required for Caspase-11 expression, thus providing the “missing link” for the role of Caspase-8 in endotoxicity.