Scholarlink

<p>Non-coding RNAs, as microRNAs, long non-coding RNAs, and circular RNAs, are significant modulators of tumor biology and gene expression. miRNAs primarily regulate gene expression at the post-transcriptional level, whereas lncRNAs influence transcriptional activity and epigenetic states. Moreover, circRNAs function as highly stable molecules that shape oncogenic pathways by sequestering miRNAs and interacting with RNA-binding proteins. By addressing these regulatory roles, ncRNAs have emerged as attractive candidates for therapeutic intervention, yet their clinical translation remains limited by rapid degradation, insufficient cellular uptake, and off-target effects. Engineered exosomes—natural nanosized vesicles with strong biocompatibility and barrier-crossing capacity—represent a promising platform to overcome these delivery challenges. This review provides a comprehensive overview of recent advances in exosome engineering for cancer-directed ncRNA delivery. We summarize state-of-the-art strategies designed to enhance loading efficiency, targeting specificity, and therapeutic performance of exosome-mediated delivery systems for miRNAs, lncRNAs, and circRNAs, and outline their growing potential in next-generation cancer therapy.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Target therapeutic exploitation of engineered exosome-mediated delivery of ncRNAs in cancer

  • 期刊论文

  • 发表日期：

    2026年7月21日

查看全文
  • Fatemeh Chaharlang,
  • Nafiseh Mahdipour,
  • Sana Alizadeh Rami,
  • Parichehr Angouti,
  • Alireza Ahmadi,
  • Mohammad Khalaj-Kondori

摘要

Non-coding RNAs, as microRNAs, long non-coding RNAs, and circular RNAs, are significant modulators of tumor biology and gene expression. miRNAs primarily regulate gene expression at the post-transcriptional level, whereas lncRNAs influence transcriptional activity and epigenetic states. Moreover, circRNAs function as highly stable molecules that shape oncogenic pathways by sequestering miRNAs and interacting with RNA-binding proteins. By addressing these regulatory roles, ncRNAs have emerged as attractive candidates for therapeutic intervention, yet their clinical translation remains limited by rapid degradation, insufficient cellular uptake, and off-target effects. Engineered exosomes—natural nanosized vesicles with strong biocompatibility and barrier-crossing capacity—represent a promising platform to overcome these delivery challenges. This review provides a comprehensive overview of recent advances in exosome engineering for cancer-directed ncRNA delivery. We summarize state-of-the-art strategies designed to enhance loading efficiency, targeting specificity, and therapeutic performance of exosome-mediated delivery systems for miRNAs, lncRNAs, and circRNAs, and outline their growing potential in next-generation cancer therapy.