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<p>Tumor metastasis regulated by multiple complicated pathways is closely related to variations in the tumor microenvironment (TME). Exosomes can regulate the TME through various mechanisms. Exosomes derived from tumor cells carry a variety of substances, including long non-coding RNAs (lncRNAs), play important roles in intercellular communication and act as critical determinants influencing tumor metastasis. In this review, we elaborate on several pivotal processes through which lncRNAs regulate tumor metastasis, including the regulation of epithelial‒mesenchymal transition, promotion of angiogenesis and lymphangiogenesis, enhancement of the stemness of tumor cells, and evasion of immune clearance. Additionally, we comprehensively summarized a diverse array of potential tumor-derived exosomal lncRNA biomarkers to facilitate accurate diagnosis and prognosis in a clinical setting.</p>

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The role of tumor-derived exosomal LncRNA in tumor metastasis

  • 期刊论文

  • 发表日期：

    2025年2月26日

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  • Zhile Yu,
  • Jiali Fu,
  • Vanya Mantareva,
  • Ivica Blažević,
  • Yusong Wu,
  • Dianchang Wen,
  • Tungalag Battulga,
  • Yuqing Wang,
  • Jianye Zhang

摘要

Tumor metastasis regulated by multiple complicated pathways is closely related to variations in the tumor microenvironment (TME). Exosomes can regulate the TME through various mechanisms. Exosomes derived from tumor cells carry a variety of substances, including long non-coding RNAs (lncRNAs), play important roles in intercellular communication and act as critical determinants influencing tumor metastasis. In this review, we elaborate on several pivotal processes through which lncRNAs regulate tumor metastasis, including the regulation of epithelial‒mesenchymal transition, promotion of angiogenesis and lymphangiogenesis, enhancement of the stemness of tumor cells, and evasion of immune clearance. Additionally, we comprehensively summarized a diverse array of potential tumor-derived exosomal lncRNA biomarkers to facilitate accurate diagnosis and prognosis in a clinical setting.