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Background <p>People with a cancer signal detected via multi-cancer early detection (MCED) screening need timely access to confirmatory diagnostic testing. We estimated the likely change in demand for diagnostic testing in England if MCED screening were introduced.</p> Methods <p>Diagnostic demand was modelled based on (1) estimates of the volume of people aged 50–79 years who would be referred for diagnostic investigation following a ‘cancer signal detected’ result after MCED screening and (2) MCED test performance metrics. Predicted usage was compared with current annual usage using routine NHS datasets.</p> Results <p>In an established MCED screening programme, assuming 70% of the total eligible population is screened annually (~13 million), the relative change in diagnostic demand was greatest for colonoscopy (+2.09%; +13,730 each year); the greatest absolute change was for computed tomography (CT; +0.76%; +62,320). This equates to +1040 colonoscopies and +4720 CT scans for every million screened.</p> Conclusions <p>The predicted relative increase in diagnostic testing generated by MCED screening is small, though a large eligible population and maximum uptake could translate into a large number of procedures. Cancer diagnoses brought forward in time through screening should reduce diagnostic use for symptomatic presentations in the future.</p>

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Modelled impact of a multi-cancer early detection screening programme on the demand for diagnostics in England

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月31日

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  • Joanne Martin,
  • David A. Jones,
  • Libby Ellis,
  • Ewan Gray,
  • Katharine Halliday,
  • Sara Hiom,
  • Sean McPhail,
  • Andrew Millar,
  • Willie Hamilton

摘要

Background

People with a cancer signal detected via multi-cancer early detection (MCED) screening need timely access to confirmatory diagnostic testing. We estimated the likely change in demand for diagnostic testing in England if MCED screening were introduced.

Methods

Diagnostic demand was modelled based on (1) estimates of the volume of people aged 50–79 years who would be referred for diagnostic investigation following a ‘cancer signal detected’ result after MCED screening and (2) MCED test performance metrics. Predicted usage was compared with current annual usage using routine NHS datasets.

Results

In an established MCED screening programme, assuming 70% of the total eligible population is screened annually (~13 million), the relative change in diagnostic demand was greatest for colonoscopy (+2.09%; +13,730 each year); the greatest absolute change was for computed tomography (CT; +0.76%; +62,320). This equates to +1040 colonoscopies and +4720 CT scans for every million screened.

Conclusions

The predicted relative increase in diagnostic testing generated by MCED screening is small, though a large eligible population and maximum uptake could translate into a large number of procedures. Cancer diagnoses brought forward in time through screening should reduce diagnostic use for symptomatic presentations in the future.