Scholarlink

Background <p>The duration from diagnosis to primary treatment initiation (DTI) is an important interval for patients with cancer, as delayed treatment has been found to be associated with heightened recurrence rates and worsened survival. Studying the association between DTI duration and overall survival (OS) is biased and confounded by clinical triaging, heterogeneous definitions, and variation in analytic approaches.</p> Objective <p>To develop consensus-based guidance for conducting studies investigating the association of DTI duration and OS.</p> Methods <p>A multidisciplinary panel was recruited to participate in a three-round modified Delphi approach to develop consensus recommendations on the best methodological practices when studying the association between DTI duration and OS.</p> Results <p>The Delphi panel consisted of 15 experts in the fields of epidemiology, biostatistics, health services research, oncology, and health policy. A list of 24 recommendations with accompanying elaborations was generated including variable definition and measurement, cohort creation, confounder control, pertinent biases, analytic techniques, and balanced interpretation of results.</p> Conclusion <p>Providing valid evidence of the DTI effect on OS requires careful approaches. This paper offers recommendations on how to improve methodological quality. This will ensure that future studies effectively contribute to evidence-informed practice decisions on appropriate waiting times for patients with cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Recommendations for studying the association of the cancer diagnosis to treatment interval with overall survival: a modified Delphi process

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月5日

查看全文
  • Matthew Jalink,
  • Will D. King,
  • Benjamin O. Anderson,
  • Rinku Sutradhar,
  • Marie Louise Tørring,
  • Michael D. Brundage,
  • Patti A. Groome,
  • Kelvin K. W. Chan,
  • Robin Urquhart,
  • Yingwei Peng,
  • Antoine Eskander,
  • Surbhi Grover,
  • Michael J. Raphael,
  • Richard Grieve,
  • Cassidy Laub,
  • Christopher M. Booth,
  • Timothy P. Hanna

摘要

Background

The duration from diagnosis to primary treatment initiation (DTI) is an important interval for patients with cancer, as delayed treatment has been found to be associated with heightened recurrence rates and worsened survival. Studying the association between DTI duration and overall survival (OS) is biased and confounded by clinical triaging, heterogeneous definitions, and variation in analytic approaches.

Objective

To develop consensus-based guidance for conducting studies investigating the association of DTI duration and OS.

Methods

A multidisciplinary panel was recruited to participate in a three-round modified Delphi approach to develop consensus recommendations on the best methodological practices when studying the association between DTI duration and OS.

Results

The Delphi panel consisted of 15 experts in the fields of epidemiology, biostatistics, health services research, oncology, and health policy. A list of 24 recommendations with accompanying elaborations was generated including variable definition and measurement, cohort creation, confounder control, pertinent biases, analytic techniques, and balanced interpretation of results.

Conclusion

Providing valid evidence of the DTI effect on OS requires careful approaches. This paper offers recommendations on how to improve methodological quality. This will ensure that future studies effectively contribute to evidence-informed practice decisions on appropriate waiting times for patients with cancer.