Scholarlink

Background <p>We examined the association of serum YKL-40, an inflammatory biomarker, with incident cancer risk in early type 2 diabetes.</p> Methods <p>A cohort of 11,346 individuals newly diagnosed with type 2 diabetes was followed for up to 14 years. YKL-40 levels (n = 9010) were categorised into five percentiles (0–33%, 34–66%, 67–90%, 91–95%, and 96–100%), and baseline YKL-40 and CRP (n = 9644) were analyzed continuously (per 1 SD log increment) for comparison. Cox regression models assessed associations with obesity-related, gastrointestinal, liver, pancreatic, colorectal, bladder and lung cancers, as well as cancers of reproductive organs.</p> Results <p>Adjusted HRs (95% CIs) for the highest versus lowest YKL-40 category were 2.4 (1.6–3.7) for obesity-related, 2.6 (1.7–4.1) for gastrointestinal, 44.2 (12.8–153.4) for liver, and 4.2 (1.3–14.1) for bladder cancers. No associations were found for other cancers. YKL-40 and CRP had similar prognostic abilities for obesity-related and gastrointestinal cancers, but YKL-40 outperformed CRP for liver and bladder cancers. Conversely, CRP was a stronger predictor for lung, colorectal, and ovarian cancers.</p> Discussion <p>YKL-40 was associated with the risks of liver and bladder cancers, clearly outperforming CRP for these cancers. This suggests distinct prognostic roles for YKL-40 and CRP, and highlights YKL-40 as a promising biomarker for liver cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月5日

查看全文
  • Alisa D. Kjaergaard,
  • Allan A. Vaag,
  • Verena H. Jensen,
  • Michael H. Olsen,
  • Kurt Højlund,
  • Peter Vestergaard,
  • Torben Hansen,
  • Reimar W. Thomsen,
  • Niels Jessen

摘要

Background

We examined the association of serum YKL-40, an inflammatory biomarker, with incident cancer risk in early type 2 diabetes.

Methods

A cohort of 11,346 individuals newly diagnosed with type 2 diabetes was followed for up to 14 years. YKL-40 levels (n = 9010) were categorised into five percentiles (0–33%, 34–66%, 67–90%, 91–95%, and 96–100%), and baseline YKL-40 and CRP (n = 9644) were analyzed continuously (per 1 SD log increment) for comparison. Cox regression models assessed associations with obesity-related, gastrointestinal, liver, pancreatic, colorectal, bladder and lung cancers, as well as cancers of reproductive organs.

Results

Adjusted HRs (95% CIs) for the highest versus lowest YKL-40 category were 2.4 (1.6–3.7) for obesity-related, 2.6 (1.7–4.1) for gastrointestinal, 44.2 (12.8–153.4) for liver, and 4.2 (1.3–14.1) for bladder cancers. No associations were found for other cancers. YKL-40 and CRP had similar prognostic abilities for obesity-related and gastrointestinal cancers, but YKL-40 outperformed CRP for liver and bladder cancers. Conversely, CRP was a stronger predictor for lung, colorectal, and ovarian cancers.

Discussion

YKL-40 was associated with the risks of liver and bladder cancers, clearly outperforming CRP for these cancers. This suggests distinct prognostic roles for YKL-40 and CRP, and highlights YKL-40 as a promising biomarker for liver cancer.