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Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年11月29日

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  • Fabian Stögbauer,
  • Markus Wirth,
  • Maren Lauterbach,
  • Barbara Wollenberg,
  • Benedikt Schmidl,
  • Cosima C. Hoch,
  • Iordanis Ourailidis,
  • Jochen Hess,
  • Markus Eckstein,
  • Arndt Hartmann,
  • Heinrich Iro,
  • Antoniu-Oreste Gostian,
  • Matthias Balk,
  • Moritz Jesinghaus,
  • Julika Ribbat-Idel,
  • Verena-Wilbeth Sailer,
  • Sven Perner,
  • Karl-Ludwig Bruchhage,
  • Markus Hoffmann,
  • Lukas Lükewille,
  • Christiane Maria Stuhlmann-Laeisz,
  • Christoph Röcken,
  • Carolin Mogler,
  • Jan Budczies,
  • Melanie Boxberg

摘要

Background

We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC).

Methods

We analyzed digitized H&E-stained slides from a multicenter cohort of five large university centers consisting of n = 275 cases of p16-positive OPSCC. We evaluated TB along with other histological parameters (morphology, tumor-stroma-ratio, lymphovascular invasion (LVI), perineural invasion) and calculated survival outcomes using both univariate and multivariate analyses.

Results

TB was identified as an independent prognostic parameter, with TB-high cases showing inferior outcomes in univariate (HR: 3.08, 95%-CI: 1.71–5.54) and multivariate analyses (HR: 4.03, 95%-CI: 1.65–9.83). Similarly, LVI remained an independent prognostic factor (HR: 3.00, 95%-CI: 1.22–7.38). A combined classification including TB and LVI stratified cases into low-, intermediate- and high-risk categories. We could not detect correlations between TB and the number of lymph node metastases or between TB and an extracapsular extension of lymph node metastases.

Conclusions

In addition to LVI, we could identify TB as an independent prognostic factor in p16-positive OPSCC in this multicenter study cohort. Thus, evaluating TB along with LVI in a combined scheme for prognostication might help to establish a more personalized treatment regimen for patients with p16-positive OPSCC.