Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity

期刊论文
出版模式：

开放获取
发表日期：

2024年2月22日

查看全文

Batel Blechter,
Jason Y. Y. Wong,
Li-Hsin Chien,
Kouya Shiraishi,
Xiao-Ou Shu,
Qiuyin Cai,
Wei Zheng,
Bu-Tian Ji,
Wei Hu,
Mohammad L. Rahman,
Hsin-Fang Jiang,
Fang-Yu Tsai,
Wen-Yi Huang,
Yu-Tang Gao,
Xijing Han,
Mark D. Steinwandel,
Gong Yang,
Yihe G. Daida,
Su-Ying Liang,
Scarlett L. Gomez,
Mindy C. DeRouen,
W. Ryan Diver,
Ananya G. Reddy,
Alpa V. Patel,
Loïc Le Marchand,
Christopher Haiman,
Takashi Kohno,
Iona Cheng,
I-Shou Chang,
Chao Agnes Hsiung,
Nathaniel Rothman,
Qing Lan

摘要

Background

We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.

Methods

We analyzed the distribution of age at lung cancer diagnosis in 33,793 individuals across 8 cohort studies and two national registries from East Asia, the United States (US) and the United Kingdom (UK). Student’s t-tests were used to assess the study population differences (Δ years) in age at diagnosis comparing females and males who never smoke across subgroups defined by race/ethnicity, geographic location, and histological subtypes.

Results

We found that among Chinese individuals diagnosed with lung cancer who never smoke, females were diagnosed with lung cancer younger than males in the Taiwan Cancer Registry (n = 29,832) (Δ years = −2.2 (95% confidence interval (CI):−2.5, −1.9), in Shanghai (n = 1049) (Δ years = −1.6 (95% CI:-2.9, −0.3), and in Sutter Health and Kaiser Permanente Hawaiʽi in the US (n = 82) (Δ years = −11.3 (95% CI: −17.7, −4.9). While there was a suggestion of similar patterns in African American and non-Hispanic White individuals. the estimated differences were not consistent across studies and were not statistically significant.

Conclusions

We found evidence of sex differences for age at lung cancer diagnosis among individuals who never smoke.