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<p>The product information leaflet for metronidazole highlights a potential interaction with propylene glycol-containing substances, which may result in a disulfiram-like reaction. While dentists routinely advise patients to avoid alcohol during metronidazole therapy for this reason, there is limited awareness within the dental profession that e-cigarette liquids also contain propylene glycol and may pose a similar risk. This case report highlights a suspected drug interaction between metronidazole and propylene glycol from e-cigarette use, leading to a disulfiram-like reaction in a healthy 25-year-old male. Thorough history-taking and clear patient guidance regarding vaping habits are essential for the safe prescribing of metronidazole and vigilant monitoring for adverse reactions, as outlined in the practice recommendations at the end of this report.</p>

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Disulfiram-like reaction due to the interaction between vaping and metronidazole: a case report

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Matt Strickland-Baker

摘要

The product information leaflet for metronidazole highlights a potential interaction with propylene glycol-containing substances, which may result in a disulfiram-like reaction. While dentists routinely advise patients to avoid alcohol during metronidazole therapy for this reason, there is limited awareness within the dental profession that e-cigarette liquids also contain propylene glycol and may pose a similar risk. This case report highlights a suspected drug interaction between metronidazole and propylene glycol from e-cigarette use, leading to a disulfiram-like reaction in a healthy 25-year-old male. Thorough history-taking and clear patient guidance regarding vaping habits are essential for the safe prescribing of metronidazole and vigilant monitoring for adverse reactions, as outlined in the practice recommendations at the end of this report.