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<p>Long-term survivors after allogeneic cell transplantation (HCT) have unique needs. We performed a cross-sectional case-control study to describe the survivorship profile of 244 adult allogeneic transplantation recipients at a median of 8.4 years post-HCT and compared it to controls from the general population (matched 1:3 based on age, gender, and province of residence). The most prevalent medical complications were graft versus host disease (46.7%), impaired kidney function (63.9%), and the presence of a metabolic syndrome (33.6%). Survivors were significantly more likely to report a sub-optimal perceived health status than controls (82.0% versus 52.1% respectively, OR 4.57, <i>p</i> &lt; 0.0001). They also reported significantly lower employment rates (42.6% versus 55.6% respectively, OR 0.389, <i>p</i> &lt; 0.0001) and more polypharmacy (32.0% versus 9.6% respectively, OR 5.0, <i>p</i> &lt; 0.0001) than matched counterparts. Social support and mental health were generally preserved. Apart for a concerning tendency to medication non-adherence, low physical activity (54.5%), and inappropriate exposition to UV (44.7%), health-related behavior was adequate. Many survivors have a health status comparable to chronically ill patients and, if so, should be managed as such. Novel patient-centered initiatives based on chronic care models could support survivors in preventing and dealing with long-term complications, regaining functionality, and returning to their role in society.</p><p></p>

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Life 2.0: a comprehensive cross-sectional profiling of long-term allogeneic hematopoietic cell transplantation survivors compared to a matched general population cohort

  • 期刊论文

  • 发表日期：

    2025年2月6日

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  • Hélène Schoemans,
  • Kathy Goris,
  • Steffen Fieuws,
  • Koen Theunissen,
  • Kristel Buvé,
  • Liesbet Lammertijn,
  • Greet Bries,
  • Hilde Demuynck,
  • Vincent Maertens,
  • Helena Maes,
  • Stef Meers,
  • Christine Schuermans,
  • Inge Vrelust,
  • Hadewijch De Samblanx,
  • Griet Huysmans,
  • Vibeke Vergote,
  • Marielle Beckers,
  • Johan Maertens,
  • Sabina De Geest,
  • Fabienne Dobbels

摘要

Long-term survivors after allogeneic cell transplantation (HCT) have unique needs. We performed a cross-sectional case-control study to describe the survivorship profile of 244 adult allogeneic transplantation recipients at a median of 8.4 years post-HCT and compared it to controls from the general population (matched 1:3 based on age, gender, and province of residence). The most prevalent medical complications were graft versus host disease (46.7%), impaired kidney function (63.9%), and the presence of a metabolic syndrome (33.6%). Survivors were significantly more likely to report a sub-optimal perceived health status than controls (82.0% versus 52.1% respectively, OR 4.57, p < 0.0001). They also reported significantly lower employment rates (42.6% versus 55.6% respectively, OR 0.389, p < 0.0001) and more polypharmacy (32.0% versus 9.6% respectively, OR 5.0, p < 0.0001) than matched counterparts. Social support and mental health were generally preserved. Apart for a concerning tendency to medication non-adherence, low physical activity (54.5%), and inappropriate exposition to UV (44.7%), health-related behavior was adequate. Many survivors have a health status comparable to chronically ill patients and, if so, should be managed as such. Novel patient-centered initiatives based on chronic care models could support survivors in preventing and dealing with long-term complications, regaining functionality, and returning to their role in society.