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<p>There is a clear link between type 2 diabetes mellitus (DM) and overall cancer risk. However, studies evaluating type 2 DM and multiple myeloma (MM) risk are limited, and the association is less clear. Understanding the impact of longstanding type 2 DM on organ systems and symptomatology in patients with a subsequent MM diagnosis, alongside potential overlapping toxicities from MM treatment, is crucial. This review summarizes the role of type 2 DM on MM risk and outcomes and explores the various mechanisms underlying these associations. A better understanding of this association will help improve outcomes in diabetic MM patients through lifestyle and drug related interventions. Clinical trial registration: Not applicable.</p>

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Diabetes mellitus in multiple myeloma and related plasma cell disorders: a review of risk, prognosis, and outcomes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月24日

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  • R Parikh,
  • RP Thirugnanasambandam,
  • UA Shah

摘要

There is a clear link between type 2 diabetes mellitus (DM) and overall cancer risk. However, studies evaluating type 2 DM and multiple myeloma (MM) risk are limited, and the association is less clear. Understanding the impact of longstanding type 2 DM on organ systems and symptomatology in patients with a subsequent MM diagnosis, alongside potential overlapping toxicities from MM treatment, is crucial. This review summarizes the role of type 2 DM on MM risk and outcomes and explores the various mechanisms underlying these associations. A better understanding of this association will help improve outcomes in diabetic MM patients through lifestyle and drug related interventions. Clinical trial registration: Not applicable.