Scholarlink

<p>Emerging evidence highlights that tumor metastasis is critically regulated by key dynamic vascular components, including endothelial cells (ECs) and pericytes, which engage in persistent intercellular crosstalk, both with one another and with other cell types in the tumor microenvironment. These interactions drive not only the structural and functional remodeling of vessels but also the assembly of immunosuppressive clusters that support metastatic dissemination. By synthesizing recent advances, this review aims to establish a new conceptual framework focused on spatiotemporal dynamics and functional interactions within the vascular niche. This framework elucidates the mechanisms through which vascular components dynamically evolve and cooperate to drive metastasis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis

  • 期刊论文

  • 发表日期：

    2026年5月19日

查看全文
  • Qun Miao,
  • Rong Chen,
  • Dong-mei Zhang,
  • Jun-qiu Zhang,
  • Min-feng Chen

摘要

Emerging evidence highlights that tumor metastasis is critically regulated by key dynamic vascular components, including endothelial cells (ECs) and pericytes, which engage in persistent intercellular crosstalk, both with one another and with other cell types in the tumor microenvironment. These interactions drive not only the structural and functional remodeling of vessels but also the assembly of immunosuppressive clusters that support metastatic dissemination. By synthesizing recent advances, this review aims to establish a new conceptual framework focused on spatiotemporal dynamics and functional interactions within the vascular niche. This framework elucidates the mechanisms through which vascular components dynamically evolve and cooperate to drive metastasis.