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<p>The ability to differentiate between rewarding and aversive stimuli is crucial for survival, yet the underlying neural mechanisms allowing animals to make such a distinction remain elusive. Here, using in vivo two-photon calcium imaging, we uncovered how the activity of dopamine-sensitive neurons in the medial nucleus of the central amygdala (CeM) is associated with appetitive and aversive experiences. We found that cocaine and sucrose strongly activated DRD1(+) neurons while suppressing DRD2(+) activity, whereas the aversive quinine stimulus predominantly engaged DRD2(+) neurons, particularly those not previously recruited by sucrose. Our findings suggest that DRD1(+) and DRD2(+) neurons differentially contribute to the processing of appetitive and aversive stimuli. Furthermore, by simultaneously monitoring facial expressions, we identified stimulus-specific behavioral responses to sucrose, quinine, and cocaine.</p>

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DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Łukasz Bijoch,
  • Justyna Wiśniewska,
  • Paweł Szczypkowski,
  • Monika Pawłowska,
  • Karolina Hajdukiewicz,
  • Radek Lapkiewicz,
  • Anna Beroun

摘要

The ability to differentiate between rewarding and aversive stimuli is crucial for survival, yet the underlying neural mechanisms allowing animals to make such a distinction remain elusive. Here, using in vivo two-photon calcium imaging, we uncovered how the activity of dopamine-sensitive neurons in the medial nucleus of the central amygdala (CeM) is associated with appetitive and aversive experiences. We found that cocaine and sucrose strongly activated DRD1(+) neurons while suppressing DRD2(+) activity, whereas the aversive quinine stimulus predominantly engaged DRD2(+) neurons, particularly those not previously recruited by sucrose. Our findings suggest that DRD1(+) and DRD2(+) neurons differentially contribute to the processing of appetitive and aversive stimuli. Furthermore, by simultaneously monitoring facial expressions, we identified stimulus-specific behavioral responses to sucrose, quinine, and cocaine.