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<p>This study investigated associations between bullying victimization and brain development using longitudinal structural MRI data from the IMAGEN cohort (n = 2094; 1009 females) across three time points (∼14, ∼19, and ∼22 years). A data-driven analysis revealed that higher bullying victimization was significantly associated with accelerated volumetric growth in subcortical and limbic regions, including the putamen (β = 0.12, 95% CI: 0.10–0.15), amygdala (β = 0.07, 95% CI: 0.05–0.09), hippocampus (β = 0.06, 95% CI: 0.04–0.08), and anterior cingulate cortex (caudal: β = 0.05, 95% CI: 0.03–0.07; rostral: β = 0.06, 95% CI: 0.04–0.08). In contrast, bullying victimization was also significantly associated with reduced volumetric growth in the cerebellum (β = −0.09, 95% CI: −0.11 to −0.07), entorhinal cortex (β = −0.10, 95% CI: −0.13 to −0.07), and insula (β = −0.08, 95% CI: −0.11 to −0.06). Exploratory analyses indicated that females exhibited more pronounced changes in emotional processing regions, while males showed greater changes in motor and sensory areas. Overall, the findings indicate that bullying victimization is associated with widespread structural differences in brain development from adolescence to early adulthood, with sex-specific trajectories.</p>

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Bullying victimization and brain development: a longitudinal structural magnetic resonance imaging study from adolescence to early adulthood

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Michael Connaughton,
  • Orla Mitchell,
  • Emer Cullen,
  • Michael O’Connor,
  • Tobias Banaschewski,
  • Gareth J. Barker,
  • Arun L. W. Bokde,
  • Rüdiger Brühl,
  • Sylvane Desrivières,
  • Herta Flor,
  • Hugh Garavan,
  • Penny Gowland,
  • Antoine Grigis,
  • Andreas Heinz,
  • Herve Lemaitre,
  • Jean-Luc Martinot,
  • Marie-Laure Paillère Martinot,
  • Eric Artiges,
  • Frauke Nees,
  • Dimitri Papadopoulos Orfanos,
  • Luise Poustka,
  • Michael N. Smolka,
  • Sarah Hohmann,
  • Nathalie Holz,
  • Nilakshi Vaidya,
  • Henrik Walter,
  • Gunter Schumann,
  • Robert Whelan,
  • Darren Roddy

摘要

This study investigated associations between bullying victimization and brain development using longitudinal structural MRI data from the IMAGEN cohort (n = 2094; 1009 females) across three time points (∼14, ∼19, and ∼22 years). A data-driven analysis revealed that higher bullying victimization was significantly associated with accelerated volumetric growth in subcortical and limbic regions, including the putamen (β = 0.12, 95% CI: 0.10–0.15), amygdala (β = 0.07, 95% CI: 0.05–0.09), hippocampus (β = 0.06, 95% CI: 0.04–0.08), and anterior cingulate cortex (caudal: β = 0.05, 95% CI: 0.03–0.07; rostral: β = 0.06, 95% CI: 0.04–0.08). In contrast, bullying victimization was also significantly associated with reduced volumetric growth in the cerebellum (β = −0.09, 95% CI: −0.11 to −0.07), entorhinal cortex (β = −0.10, 95% CI: −0.13 to −0.07), and insula (β = −0.08, 95% CI: −0.11 to −0.06). Exploratory analyses indicated that females exhibited more pronounced changes in emotional processing regions, while males showed greater changes in motor and sensory areas. Overall, the findings indicate that bullying victimization is associated with widespread structural differences in brain development from adolescence to early adulthood, with sex-specific trajectories.