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Background <p>This systematic review aims to synthesize anatomical and functional magnetic resonance imaging (MRI) findings in the subgenual anterior cingulate cortex (sgACC) and associated network among medication-free patients with major depressive disorder (MDD) compared to healthy controls.</p> Methods <p>A search for published studies was performed through Ovid (MEDLINE, Embase, APA PsycINFO) on 18 April 2024. The JBI Critical Appraisal Tools and a modified version of the specialist protocol for MRI research were used for the quality assessment. Random-effects and activation likelihood estimation (ALE) meta-analyses were applied to studies reporting numerical and stereotactic data, respectively.</p> Results <p>Forty-two publications were reviewed. There was an equal split between the number of studies (<i>n</i> = 5) reporting reduced sgACC GM volume vs. no difference in MDD, with both findings supported by significant ALE clusters with peaks in the right sgACC (<i>p</i> ≤ .0005). Four task-based activity studies reported overactive sgACC in MDD, whereas 6 reported no difference. Both findings were supported by two significant ALE clusters with peaks in the right sgACC (<i>p</i> ≤ .00001). Eleven studies highlighted the global reduced resting-state network coherence of the sgACC in MDD, and reduced coherence with ventromedial prefrontal cortex (<i>p</i> = .00004) and right insula (<i>p</i> = .00002) was replicated across several reports.</p> Conclusions <p>Results highlight laterality and voxel-wise differences across subregions of the sgACC, displaying non-uniform GM volume, activity, and network coherence patterns in MDD. High-resolution parcellation of the sgACC should be considered in future MRI investigations.</p>

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Subgenual anterior cingulate cortex in major depression: a systematic review and meta-analysis of MRI studies with patients and healthy controls

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  • 发表日期：

    2026年3月31日

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  • Ilya Demchenko,
  • Rachel L. Sousa-Ho,
  • Vanessa A. Baltazar,
  • Ishaan Tailor,
  • Niloy Roy,
  • Tom A. Schweizer,
  • Sidney H. Kennedy,
  • Alexandre Boutet,
  • Andres M. Lozano,
  • Katharine Dunlop,
  • Venkat Bhat

摘要

Background

This systematic review aims to synthesize anatomical and functional magnetic resonance imaging (MRI) findings in the subgenual anterior cingulate cortex (sgACC) and associated network among medication-free patients with major depressive disorder (MDD) compared to healthy controls.

Methods

A search for published studies was performed through Ovid (MEDLINE, Embase, APA PsycINFO) on 18 April 2024. The JBI Critical Appraisal Tools and a modified version of the specialist protocol for MRI research were used for the quality assessment. Random-effects and activation likelihood estimation (ALE) meta-analyses were applied to studies reporting numerical and stereotactic data, respectively.

Results

Forty-two publications were reviewed. There was an equal split between the number of studies (n = 5) reporting reduced sgACC GM volume vs. no difference in MDD, with both findings supported by significant ALE clusters with peaks in the right sgACC (p ≤ .0005). Four task-based activity studies reported overactive sgACC in MDD, whereas 6 reported no difference. Both findings were supported by two significant ALE clusters with peaks in the right sgACC (p ≤ .00001). Eleven studies highlighted the global reduced resting-state network coherence of the sgACC in MDD, and reduced coherence with ventromedial prefrontal cortex (p = .00004) and right insula (p = .00002) was replicated across several reports.

Conclusions

Results highlight laterality and voxel-wise differences across subregions of the sgACC, displaying non-uniform GM volume, activity, and network coherence patterns in MDD. High-resolution parcellation of the sgACC should be considered in future MRI investigations.